Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 45241..46864 Replicon plasmid p17Sal018
Accession NZ_CP069167
Organism Salmonella enterica strain GSJ/2016-Sal.-018

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag FJR58_RS23955 Protein ID WP_000088046.1
Coordinates 45539..46864 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag FJR58_RS23950 Protein ID WP_024136327.1
Coordinates 45241..45534 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJR58_RS23925 41113..42354 + 1242 WP_001053338.1 VWA domain-containing protein -
FJR58_RS23930 42917..43198 - 282 WP_000077926.1 hypothetical protein -
FJR58_RS23935 43248..43439 - 192 WP_000398480.1 hypothetical protein -
FJR58_RS23940 43531..43872 - 342 WP_001151575.1 hypothetical protein -
FJR58_RS23945 44245..44637 + 393 WP_000341066.1 hypothetical protein -
FJR58_RS23950 45241..45534 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
FJR58_RS23955 45539..46864 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
FJR58_RS23960 46925..47131 + 207 WP_000134171.1 hypothetical protein -
FJR58_RS23965 47233..47643 + 411 WP_000985911.1 hypothetical protein -
FJR58_RS23970 47656..48471 + 816 WP_001572439.1 HNH endonuclease -
FJR58_RS23975 48725..49150 + 426 WP_001043843.1 hypothetical protein -
FJR58_RS23980 49699..50007 + 309 WP_001224687.1 hypothetical protein -
FJR58_RS23985 50023..50880 + 858 WP_000784387.1 HNH endonuclease -
FJR58_RS23990 50942..51145 + 204 WP_001194555.1 hypothetical protein -
FJR58_RS23995 51487..51771 - 285 Protein_60 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..217773 217773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T190011 WP_000088046.1 NZ_CP069167:45539-46864 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T190011 NZ_CP091061:797924-798334 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT190011 WP_024136327.1 NZ_CP069167:45241-45534 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT190011 NZ_CP091061:797677-797943 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References