Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1545324..1546374 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JN139_RS07325 Protein ID WP_003407164.1
Coordinates 1545324..1546145 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JN139_RS07330 Protein ID WP_003407167.1
Coordinates 1546138..1546374 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS07305 1540882..1541544 - 663 WP_003407152.1 membrane protein -
JN139_RS07310 1541541..1542326 - 786 WP_003407157.1 membrane protein -
JN139_RS07315 1542617..1544578 - 1962 WP_003407159.1 sigma-F factor regulator -
JN139_RS07320 1544717..1545103 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
JN139_RS07325 1545324..1546145 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JN139_RS07330 1546138..1546374 + 237 WP_003407167.1 hypothetical protein Antitoxin
JN139_RS07335 1546446..1547651 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
JN139_RS07340 1547954..1548739 + 786 WP_003407180.1 lipoprotein LprF -
JN139_RS07345 1548935..1550404 + 1470 WP_003900326.1 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T189606 WP_003407164.1 NZ_CP069074:1545324-1546145 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T189606 NZ_CP090886:1467584-1467838 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT189606 WP_003407167.1 NZ_CP069074:1546138-1546374 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT189606 NZ_CP090886:1467340-1467582 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References