Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707503..708146 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN139_RS03220 Protein ID WP_003403187.1
Coordinates 707745..708146 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN139_RS03215 Protein ID WP_003403184.1
Coordinates 707503..707748 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS03180 702783..703313 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN139_RS03185 703297..703992 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN139_RS03190 704115..704426 + 312 WP_003403164.1 hypothetical protein -
JN139_RS03195 704498..705448 + 951 WP_003900184.1 DUF1259 domain-containing protein -
JN139_RS03200 705689..706273 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN139_RS03205 706275..706985 + 711 Protein_634 IS607 family element RNA-guided endonuclease TnpB -
JN139_RS03210 706988..707458 + 471 WP_003898523.1 hypothetical protein -
JN139_RS03215 707503..707748 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN139_RS03220 707745..708146 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN139_RS03225 708137..708316 + 180 Protein_638 hypothetical protein -
JN139_RS03230 708734..708931 - 198 WP_003403191.1 hypothetical protein -
JN139_RS03235 709011..710168 - 1158 WP_003898524.1 hypothetical protein -
JN139_RS03240 710220..710441 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN139_RS03245 710583..711188 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189590 WP_003403187.1 NZ_CP069074:707745-708146 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189590 NZ_CP090882:1073632-1074390 [Streptococcus pneumoniae]
ATGGATATCCAAGATTATACTGATAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTTCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAATATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAAGAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAATACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATTAACCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189590 WP_003403184.1 NZ_CP069074:707503-707748 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189590 NZ_CP090882:1073156-1073632 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACCCAACCCGAATTTGCACGGATTGTAGGTATTTC
ACGTAATAGTCTGAGTCGATATGAAAATGGAACGAGTTCAGTTTCTACGGAACTAATAGACATCATTTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTAACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCGAATCTATTATCTCGACTCTATCGTTATCAAGATAATCGGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATTTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References