Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/- |
| Location | 2975608..2976256 | Replicon | chromosome |
| Accession | NZ_CP069072 | ||
| Organism | Mycobacterium tuberculosis strain N1216 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | - |
| Locus tag | JN141_RS14040 | Protein ID | WP_031580260.1 |
| Coordinates | 2975608..2975931 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
| Locus tag | JN141_RS14045 | Protein ID | WP_003899415.1 |
| Coordinates | 2976011..2976256 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN141_RS14010 | 2970931..2971929 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
| JN141_RS14015 | 2971943..2972407 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
| JN141_RS14020 | 2972395..2972646 | + | 252 | WP_003908028.1 | hypothetical protein | - |
| JN141_RS14025 | 2972817..2974256 | - | 1440 | WP_003899411.1 | phage major capsid protein | - |
| JN141_RS14030 | 2974264..2974797 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
| JN141_RS14035 | 2974950..2975441 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
| JN141_RS14040 | 2975608..2975931 | - | 324 | WP_031580260.1 | type II toxin-antitoxin system toxin | Toxin |
| JN141_RS14045 | 2976011..2976256 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| JN141_RS14050 | 2976253..2977680 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
| JN141_RS14055 | 2977682..2978074 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
| JN141_RS14060 | 2978071..2978331 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
| JN141_RS14065 | 2978348..2978710 | - | 363 | WP_003900543.1 | hypothetical protein | - |
| JN141_RS14070 | 2978713..2979840 | - | 1128 | WP_031650930.1 | site-specific integrase | - |
| JN141_RS14075 | 2979985..2980212 | - | 228 | WP_003899421.1 | hypothetical protein | - |
| JN141_RS14080 | 2980209..2980598 | - | 390 | WP_003899422.1 | hypothetical protein | - |
| JN141_RS14085 | 2980504..2980776 | + | 273 | WP_003900544.1 | hypothetical protein | - |
| JN141_RS14090 | 2980875..2981108 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2970931..2979840 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12344.85 Da Isoelectric Point: 8.6717
>T189508 WP_031580260.1 NZ_CP069072:c2975931-2975608 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRLHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRLHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T189508 NZ_CP090796:c299437-299150 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT189508 WP_003899415.1 NZ_CP069072:c2976256-2976011 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT189508 NZ_CP090796:c299746-299444 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTGGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTGGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|