Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975608..2976256 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag JN141_RS14040 Protein ID WP_031580260.1
Coordinates 2975608..2975931 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN141_RS14045 Protein ID WP_003899415.1
Coordinates 2976011..2976256 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS14010 2970931..2971929 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN141_RS14015 2971943..2972407 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN141_RS14020 2972395..2972646 + 252 WP_003908028.1 hypothetical protein -
JN141_RS14025 2972817..2974256 - 1440 WP_003899411.1 phage major capsid protein -
JN141_RS14030 2974264..2974797 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN141_RS14035 2974950..2975441 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN141_RS14040 2975608..2975931 - 324 WP_031580260.1 type II toxin-antitoxin system toxin Toxin
JN141_RS14045 2976011..2976256 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN141_RS14050 2976253..2977680 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JN141_RS14055 2977682..2978074 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN141_RS14060 2978071..2978331 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN141_RS14065 2978348..2978710 - 363 WP_003900543.1 hypothetical protein -
JN141_RS14070 2978713..2979840 - 1128 WP_031650930.1 site-specific integrase -
JN141_RS14075 2979985..2980212 - 228 WP_003899421.1 hypothetical protein -
JN141_RS14080 2980209..2980598 - 390 WP_003899422.1 hypothetical protein -
JN141_RS14085 2980504..2980776 + 273 WP_003900544.1 hypothetical protein -
JN141_RS14090 2980875..2981108 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970931..2979840 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12344.85 Da        Isoelectric Point: 8.6717

>T189508 WP_031580260.1 NZ_CP069072:c2975931-2975608 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRLHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189508 NZ_CP090796:c299437-299150 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189508 WP_003899415.1 NZ_CP069072:c2976256-2976011 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189508 NZ_CP090796:c299746-299444 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTGGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References