Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2873888..2874597 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag JN150_RS13450 Protein ID WP_003413164.1
Coordinates 2873888..2874301 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag JN150_RS13455 Protein ID WP_003413167.1
Coordinates 2874340..2874597 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS13420 2869598..2869912 + 315 WP_009937839.1 hypothetical protein -
JN150_RS13425 2870208..2871419 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
JN150_RS13430 2871546..2872205 + 660 WP_050069193.1 LppA family lipoprotein -
JN150_RS13435 2872202..2872861 + 660 WP_003900847.1 LppA family lipoprotein -
JN150_RS13440 2872858..2873493 + 636 WP_031685723.1 LppA family lipoprotein -
JN150_RS13445 2873517..2873795 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
JN150_RS13450 2873888..2874301 + 414 WP_003413164.1 PIN domain nuclease Toxin
JN150_RS13455 2874340..2874597 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
JN150_RS13460 2874594..2874971 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
JN150_RS13465 2874987..2875361 - 375 WP_003413177.1 hypothetical protein -
JN150_RS13470 2875461..2875856 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
JN150_RS13475 2875853..2876098 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
JN150_RS13480 2876509..2876928 - 420 WP_003413190.1 A24 family peptidase -
JN150_RS13485 2876940..2877749 - 810 WP_003413193.1 shikimate dehydrogenase -
JN150_RS13490 2877746..2878999 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
JN150_RS13495 2878992..2879504 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T188965 WP_003413164.1 NZ_CP069063:2873888-2874301 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T188965 NZ_CP090596:c515493-515242 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAATATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAAGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT188965 WP_003413167.1 NZ_CP069063:2874340-2874597 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT188965 NZ_CP090596:c515245-514991 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAAAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAATCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References