Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 720983..721647 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag JN150_RS03300 Protein ID WP_003403246.1
Coordinates 721240..721647 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN150_RS03295 Protein ID WP_050069288.1
Coordinates 720983..721243 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS03270 717160..718317 + 1158 WP_003903091.1 hypothetical protein -
JN150_RS03275 718328..719275 + 948 WP_050069287.1 DUF732 domain-containing protein -
JN150_RS03280 719368..719622 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
JN150_RS03285 719622..720017 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
JN150_RS03290 720111..720851 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN150_RS03295 720983..721243 + 261 WP_050069288.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN150_RS03300 721240..721647 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
JN150_RS03305 721719..722870 - 1152 WP_050069289.1 FIST N-terminal domain-containing protein -
JN150_RS03310 722963..724690 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T188933 WP_003403246.1 NZ_CP069063:721240-721647 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T188933 NZ_CP090593:c4435779-4435492 [Pectobacterium aroidearum]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9493.83 Da        Isoelectric Point: 11.7137

>AT188933 WP_050069288.1 NZ_CP069063:720983-721243 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRDDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT188933 NZ_CP090593:c4436023-4435769 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure

References