Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4946315..4946831 Replicon chromosome
Accession NZ_CP069046
Organism Klebsiella pneumoniae strain 33Kpn22

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IFY68_RS24275 Protein ID WP_002886902.1
Coordinates 4946315..4946599 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IFY68_RS24280 Protein ID WP_002886901.1
Coordinates 4946589..4946831 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY68_RS24250 4941799..4942107 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IFY68_RS24255 4942192..4942365 + 174 WP_002886906.1 hypothetical protein -
IFY68_RS24260 4942368..4943111 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IFY68_RS24265 4943468..4945606 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IFY68_RS24270 4945847..4946311 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IFY68_RS24275 4946315..4946599 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IFY68_RS24280 4946589..4946831 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IFY68_RS24285 4946909..4948819 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IFY68_RS24290 4948842..4949996 - 1155 WP_002886900.1 lactonase family protein -
IFY68_RS24295 4950062..4950802 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T188850 WP_002886902.1 NZ_CP069046:c4946599-4946315 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T188850 NZ_CP090587:c4499899-4498565 [Pectobacterium aroidearum]
ATGCCTCGAATACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGACCAGAGGCGAAGA
TAGGTTGCAATACCTTCCCGAATGGATTGCTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAAATTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGAAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGCTTTGTGGCGCAGAGATCGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAGAAAACGGCTTTACTCTGGCATGAAGGGCAATGGTGCTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGGATTCCTGTCGCAAAAACGCAAATTGCACAGTTTGAAGAGCAGAAGGCACTGGTTGTTGAGCGTTTT
GATAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGTCCGGGGATTTCCGATATTATGGAAATACTGAGTCATTCAGAGCAGGCTGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCACTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGCAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGCAGGCGACAGGTTGAAGCCATGATGGATGATATT
ATATCCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCAGCGTAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT188850 WP_002886901.1 NZ_CP069046:c4946831-4946589 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT188850 NZ_CP090587:c4500209-4499904 [Pectobacterium aroidearum]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAGGGGCTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAGCAAACCTATGCCCGCTTGGAAGCAAACCCCGGCAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTAACTATTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAGAGTGCATTTCTCTATG
TCATCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References