Detailed information of TA system TA188692

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3443248..3444083
• Replicon: chromosome
• Accession: NZ_CP068827
• Organism: Escherichia coli strain RIVM_C030371

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A5F0P695
• Locus tag: JNN58_RS16340
• Protein ID: WP_022645116.1
• Coordinates: 3443248..3443625 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JNN58_RS16345
• Protein ID: WP_078046143.1
• Coordinates: 3443715..3444083 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN58_RS16320	3439615..3441153	-	1539	WP_001187178.1	lysine decarboxylation/transport transcriptional activator CadC	-
JNN58_RS16325	3441902..3442744	-	843	WP_022645115.1	DUF4942 domain-containing protein	-
JNN58_RS16330	3442829..3443023	-	195	WP_024181941.1	DUF957 domain-containing protein	-
JNN58_RS16335	3443102..3443251	-	150	Protein_3188	hypothetical protein	-
JNN58_RS16340	3443248..3443625	-	378	WP_022645116.1	TA system toxin CbtA family protein	Toxin
JNN58_RS16345	3443715..3444083	-	369	WP_078046143.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JNN58_RS16350	3444246..3444467	-	222	WP_000692345.1	DUF987 domain-containing protein	-
JNN58_RS16355	3444530..3445006	-	477	WP_022645117.1	RadC family protein	-
JNN58_RS16360	3445022..3445501	-	480	WP_001564060.1	antirestriction protein	-
JNN58_RS16365	3445767..3446585	-	819	WP_001175165.1	DUF945 domain-containing protein	-
JNN58_RS16370	3446675..3446908	-	234	WP_001278293.1	DUF905 family protein	-
JNN58_RS16375	3446914..3447591	-	678	WP_001097302.1	hypothetical protein	-
JNN58_RS16380	3447739..3448419	-	681	WP_001282921.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3432126..3477817	45691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14021.99 Da
• Isoelectric Point: 7.8045

>T188692 WP_022645116.1 NZ_CP068827:c3443625-3443248 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T188692 NZ_CP090535:2126251-2126354 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13602.39 Da
• Isoelectric Point: 6.7390

>AT188692 WP_078046143.1 NZ_CP068827:c3444083-3443715 [Escherichia coli]
VSDTLSGATHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT188692 NZ_CP090535:c2126356-2126211 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Structures

Toxin

• AlphaFold DB: A0A5F0P695