Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4380243..4381078 Replicon chromosome
Accession NZ_CP068816
Organism Escherichia coli strain RIVM_C028724

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag JNN36_RS21000 Protein ID WP_001094426.1
Coordinates 4380243..4380620 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag JNN36_RS21005 Protein ID WP_001285575.1
Coordinates 4380710..4381078 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN36_RS20975 4375746..4375925 + 180 WP_001298063.1 hypothetical protein -
JNN36_RS20980 4376324..4378360 - 2037 WP_000417001.1 hypothetical protein -
JNN36_RS20985 4379312..4379470 - 159 WP_001467148.1 hypothetical protein -
JNN36_RS20990 4379549..4379746 - 198 WP_000839272.1 DUF957 domain-containing protein -
JNN36_RS20995 4379758..4380246 - 489 WP_000761683.1 hypothetical protein -
JNN36_RS21000 4380243..4380620 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
JNN36_RS21005 4380710..4381078 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN36_RS21010 4381158..4381379 - 222 WP_000692350.1 DUF987 domain-containing protein -
JNN36_RS21015 4381466..4381942 - 477 WP_001298074.1 RadC family protein -
JNN36_RS21020 4381957..4382442 - 486 WP_000213697.1 antirestriction protein -
JNN36_RS21025 4382533..4383351 - 819 WP_001175160.1 DUF945 domain-containing protein -
JNN36_RS21030 4383441..4383674 - 234 WP_001278290.1 DUF905 family protein -
JNN36_RS21035 4383680..4384357 - 678 WP_001097301.1 hypothetical protein -
JNN36_RS21040 4384505..4385185 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T188351 WP_001094426.1 NZ_CP068816:c4380620-4380243 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T188351 NZ_CP090402:3955899-3956051 [Shigella sp. PIB]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT188351 WP_001285575.1 NZ_CP068816:c4381078-4380710 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT188351 NZ_CP090402:c3955850-3955793 [Shigella sp. PIB]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References