Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3502298..3503133 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag JNN51_RS16735 Protein ID WP_000854821.1
Coordinates 3502298..3502675 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JNN51_RS16740 Protein ID WP_032216526.1
Coordinates 3502765..3503133 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS16715 3498665..3500203 - 1539 WP_001187178.1 lysine decarboxylation/transport transcriptional activator CadC -
JNN51_RS16720 3500952..3501794 - 843 WP_032216511.1 DUF4942 domain-containing protein -
JNN51_RS16725 3501879..3502076 - 198 WP_201358328.1 hypothetical protein -
JNN51_RS16730 3502152..3502301 - 150 Protein_3262 hypothetical protein -
JNN51_RS16735 3502298..3502675 - 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN51_RS16740 3502765..3503133 - 369 WP_032216526.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN51_RS16745 3503551..3503796 - 246 WP_201358319.1 hypothetical protein -
JNN51_RS16750 3503815..3504036 - 222 WP_001601167.1 DUF987 domain-containing protein -
JNN51_RS16755 3504105..3504581 - 477 WP_001186724.1 RadC family protein -
JNN51_RS16760 3504597..3505082 - 486 WP_032216512.1 antirestriction protein -
JNN51_RS16765 3505174..3505992 - 819 WP_053902307.1 DUF945 domain-containing protein -
JNN51_RS16770 3506091..3506324 - 234 WP_032289278.1 DUF905 family protein -
JNN51_RS16775 3506330..3507007 - 678 WP_032223228.1 hypothetical protein -
JNN51_RS16780 3507126..3508010 - 885 WP_032216515.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3491176..3518273 27097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T188054 WP_000854821.1 NZ_CP068807:c3502675-3502298 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T188054 NZ_CP090212:2750705-2750812 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13810.69 Da        Isoelectric Point: 6.2066

>AT188054 WP_032216526.1 NZ_CP068807:c3503133-3502765 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT188054 NZ_CP090212:c2750658-2750592 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References