188029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ralRA/-
Location 121686..122057 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag JNN51_RS00600 Protein ID WP_001317028.1
Coordinates 121863..122057 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 121686..121864 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS00575 117641..119014 + 1374 WP_001551034.1 ATP-dependent RNA helicase DbpA -
JNN51_RS00580 119143..120078 - 936 WP_000662472.1 tRNA 2-thiocytidine(32) synthetase TtcA -
JNN51_RS00585 120130..121365 - 1236 WP_001551035.1 site-specific integrase -
JNN51_RS00590 121367..121582 - 216 WP_000079604.1 excisionase XisR -
JNN51_RS00595 121682..121870 - 189 WP_001551036.1 DUF1187 family protein -
- 121686..121864 + 179 NuclAT_0 - Antitoxin
- 121686..121864 + 179 NuclAT_0 - Antitoxin
- 121686..121864 + 179 NuclAT_0 - Antitoxin
- 121686..121864 + 179 NuclAT_0 - Antitoxin
JNN51_RS00600 121863..122057 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
JNN51_RS00605 122114..122923 - 810 WP_001551037.1 recombination protein RecT -
JNN51_RS00610 122916..125567 - 2652 WP_001551038.1 exodeoxyribonuclease VIII -
JNN51_RS00615 125669..125944 - 276 WP_001314664.1 hypothetical protein -
JNN51_RS00620 126019..126189 - 171 WP_001551041.1 phage protein -
JNN51_RS00625 126189..126410 - 222 WP_000560221.1 killing protein KilR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 120130..167543 47413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-54)


Sequences


Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T188029 WP_001317028.1 NZ_CP068807:c122057-121863 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T188029 NZ_CP090203:4941764-4942249 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 179 bp

>AT188029 NZ_CP068807:121686-121864 [Escherichia coli]
GAGGACTGAAGTCTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGGCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7


Antitoxin

Download structure file

References