Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1619840..1620545 Replicon chromosome
Accession NZ_CP068806
Organism Escherichia coli strain RIVM_C018576

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JNN57_RS07635 Protein ID WP_000539521.1
Coordinates 1620159..1620545 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JNN57_RS07630 Protein ID WP_001280945.1
Coordinates 1619840..1620169 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN57_RS07615 1614997..1615908 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
JNN57_RS07620 1616086..1618434 + 2349 Protein_1477 EAL domain-containing protein -
JNN57_RS07625 1618442..1619770 + 1329 WP_000086879.1 GGDEF domain-containing protein -
JNN57_RS07630 1619840..1620169 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JNN57_RS07635 1620159..1620545 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JNN57_RS07640 1620771..1622096 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JNN57_RS07645 1622309..1622692 + 384 WP_000497137.1 biofilm formation regulator BssR -
JNN57_RS07650 1622803..1623918 + 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
JNN57_RS07655 1623915..1624541 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T188007 WP_000539521.1 NZ_CP068806:c1620545-1620159 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T188007 NZ_CP090196:2916654-2916761 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT188007 WP_001280945.1 NZ_CP068806:c1620169-1619840 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT188007 NZ_CP090196:c2916601-2916540 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References