Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3167766..3168561 Replicon chromosome
Accession NZ_CP068801
Organism Escherichia coli strain RIVM_C018220

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag JNN52_RS15535 Protein ID WP_000854914.1
Coordinates 3167766..3168140 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag JNN52_RS15540 Protein ID WP_001280955.1
Coordinates 3168187..3168561 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN52_RS15510 3163990..3164817 - 828 WP_031326415.1 DUF4942 domain-containing protein -
JNN52_RS15515 3164871..3166370 + 1500 WP_202847413.1 IS21 family transposase -
JNN52_RS15520 3166367..3167122 + 756 Protein_3043 IS21-like element ISEc10 family helper ATPase IstB -
JNN52_RS15525 3167171..3167266 - 96 WP_023910462.1 DUF957 domain-containing protein -
JNN52_RS15530 3167278..3167769 - 492 WP_000976857.1 hypothetical protein -
JNN52_RS15535 3167766..3168140 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
JNN52_RS15540 3168187..3168561 - 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN52_RS15545 3168724..3168945 - 222 WP_001220314.1 DUF987 domain-containing protein -
JNN52_RS15550 3169008..3169484 - 477 WP_001186773.1 RadC family protein -
JNN52_RS15555 3169500..3169985 - 486 WP_023910464.1 antirestriction protein -
JNN52_RS15560 3170076..3170894 - 819 WP_001234682.1 DUF945 domain-containing protein -
JNN52_RS15565 3171234..3172304 - 1071 WP_053886242.1 patatin-like phospholipase family protein -
JNN52_RS15570 3172301..3173206 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T187878 WP_000854914.1 NZ_CP068801:c3168140-3167766 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T187878 NZ_CP090081:c4932036-4931686 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT187878 WP_001280955.1 NZ_CP068801:c3168561-3168187 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT187878 NZ_CP090081:c4932328-4932041 [Bacillus cereus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References