Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 991488..992142 Replicon chromosome
Accession NZ_CP068801
Organism Escherichia coli strain RIVM_C018220

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag JNN52_RS04790 Protein ID WP_000244765.1
Coordinates 991735..992142 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag JNN52_RS04785 Protein ID WP_000354050.1
Coordinates 991488..991754 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN52_RS04765 987576..989009 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
JNN52_RS04770 989054..989365 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JNN52_RS04775 989529..990188 + 660 WP_000250275.1 hemolysin III family protein -
JNN52_RS04780 990265..991245 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
JNN52_RS04785 991488..991754 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
JNN52_RS04790 991735..992142 + 408 WP_000244765.1 protein YgfX Toxin
JNN52_RS04795 992182..992703 - 522 WP_001055874.1 flavodoxin FldB -
JNN52_RS04800 992815..993711 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JNN52_RS04805 993736..994446 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JNN52_RS04810 994452..996185 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T187862 WP_000244765.1 NZ_CP068801:991735-992142 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T187862 NZ_CP090067:737115-737534 [Acinetobacter sp. SH20PTE14]
ATGCCAACACAATATTTATTGGATACAAATATTTGTATCTATATCACCAAACATCAACCCGAAATTGTACGTCAGCATTT
TGAAAAACATTTACCTGACGGCAATATTTTTATTTCAGTGATTACTTTAGGTGAACTTCGCTTTGGTGCGGAAAAAAGCC
AATGGAAAGACAAAGCTTTCAAAGTTATCGATGAATTAACTTCAATCATTCCTGTTATAGAGTTAGATGAACACACCGCC
GTACACTATGCTCAAATTCGAAAACAGTTAGCGCTTCAGGGGCAAATAATTGGCAATAACGATTTATGGCTAGCTGCTCA
TGCACGATCAAATAATTGGGTCATGGTCACAAACAATGAAAAAGAATTTCTGCGTGTAGACGAATTGCAAGTTGAGAACT
GGCTCAGCAAATCTCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT187862 WP_000354050.1 NZ_CP068801:991488-991754 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT187862 NZ_CP090067:736885-737115 [Acinetobacter sp. SH20PTE14]
ATGACTACCGCAAAAGTTTTTATGACAGGCCGCAGTCAAGCCATTCGCTTACCCAAAGAATTTCGTTTTGAAGGCAAAGA
AGTAGAAATCTTCCGCCGAGGTGACGAAGTCATATTGCGAGAAAAACCAGTCACAGCAGATCAACTATTTAAAGTTTTGG
CGCAAATGCCAGACGACTTTTATGCAGAAACAAGAGTGGATGAACCACCGCAAGAACGAGAAGAGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References