Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1984731..1985233 Replicon chromosome
Accession NZ_CP068799
Organism Escherichia coli strain RIVM_C017887

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag JNN46_RS09340 Protein ID WP_000767822.1
Coordinates 1984979..1985233 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JNN46_RS09335 Protein ID WP_001259255.1
Coordinates 1984731..1984982 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN46_RS09310 1979909..1980976 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JNN46_RS09315 1980976..1982046 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
JNN46_RS09320 1982043..1983347 - 1305 WP_001297912.1 histidinol dehydrogenase -
JNN46_RS09325 1983353..1984252 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JNN46_RS09330 1984398..1984448 - 51 WP_001364200.1 his operon leader peptide -
JNN46_RS09335 1984731..1984982 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JNN46_RS09340 1984979..1985233 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JNN46_RS09345 1985316..1986140 + 825 WP_202847282.1 SDR family oxidoreductase -
JNN46_RS09350 1986186..1987115 + 930 WP_000803366.1 LysR family transcriptional regulator -
JNN46_RS09355 1987330..1987392 + 63 WP_010723108.1 membrane protein YoeI -
JNN46_RS09360 1987382..1988740 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T187800 WP_000767822.1 NZ_CP068799:1984979-1985233 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T187800 NZ_CP090005:1459324-1459734 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAATTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTGCTTCTGACTCCATGGTCTCCTGGTAACTCAATGATATGGCTGCCGCTACTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGTCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGCTTCAGTGGAAGAAAAAC
GAGTGGCGAATACTGAAAGCACCTTGGCTTACTCGTTACGGTATATTGCTGACATTAGAAGCGTTACAAGGCAAACCGCA
AAAGATCCATTTATGGGTAGCTAAAGACGCACTTTCGGAGGAAAATTGGCGTAATTTAAACCAGTTATTGCTGCAATACC
CTGATATCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT187800 WP_001259255.1 NZ_CP068799:1984731-1984982 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT187800 NZ_CP090005:1459077-1459343 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATAACCTGACAACCCAAGATAAGCAGGTATTTGTTCGATTATTAGAATGTGCGGACCCTGACT
TATTCAACTGGTTAATGAATCATGGCCGCCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References