Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 958502..959081 | Replicon | chromosome |
| Accession | NZ_CP068682 | ||
| Organism | Staphylococcus aureus strain NCCP11854 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | JKV48_RS04610 | Protein ID | WP_001025401.1 |
| Coordinates | 958502..958747 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 958716..959081 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKV48_RS04570 (JKV48_04545) | 953552..954133 | + | 582 | Protein_910 | family 1 glycosylhydrolase | - |
| JKV48_RS04575 (JKV48_04550) | 954226..955431 | - | 1206 | WP_000264751.1 | site-specific integrase | - |
| JKV48_RS04580 (JKV48_04555) | 955557..956171 | + | 615 | WP_000191458.1 | hypothetical protein | - |
| JKV48_RS04585 (JKV48_04560) | 956168..956314 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| JKV48_RS04590 (JKV48_04565) | 956350..956532 | - | 183 | WP_000705240.1 | hypothetical protein | - |
| JKV48_RS04595 (JKV48_04570) | 956602..957321 | - | 720 | WP_000358224.1 | XRE family transcriptional regulator | - |
| JKV48_RS04600 (JKV48_04575) | 957463..957681 | + | 219 | WP_001198673.1 | helix-turn-helix transcriptional regulator | - |
| JKV48_RS04605 (JKV48_04580) | 957697..958473 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| JKV48_RS04610 (JKV48_04585) | 958502..958747 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| JKV48_RS04615 (JKV48_04590) | 958716..959081 | - | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| JKV48_RS04620 (JKV48_04595) | 959136..959351 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| JKV48_RS04625 (JKV48_04600) | 959378..959641 | + | 264 | WP_001124198.1 | helix-turn-helix domain-containing protein | - |
| JKV48_RS04630 (JKV48_04605) | 959653..959814 | + | 162 | WP_031833131.1 | DUF1270 domain-containing protein | - |
| JKV48_RS04635 (JKV48_04610) | 959909..960211 | + | 303 | WP_000165371.1 | DUF2482 family protein | - |
| JKV48_RS04640 (JKV48_04615) | 960216..960476 | + | 261 | WP_000291510.1 | DUF1108 family protein | - |
| JKV48_RS04645 (JKV48_04620) | 960485..960748 | + | 264 | WP_001205732.1 | hypothetical protein | - |
| JKV48_RS04650 (JKV48_04625) | 960757..962700 | + | 1944 | WP_000700554.1 | AAA family ATPase | - |
| JKV48_RS04655 (JKV48_04630) | 962702..963622 | + | 921 | WP_000180600.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 954226..996654 | 42428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T187517 WP_001025401.1 NZ_CP068682:958502-958747 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T187517 NZ_CP089880:734099-734584 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGAATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTAGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGAATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTAGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
Antitoxin
Download Length: 366 bp
>AT187517 NZ_CP068682:c959081-958716 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
