Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1903364..1904196 Replicon chromosome
Accession NZ_CP068680
Organism Escherichia coli strain NCCP12480

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag JKV47_RS09165 Protein ID WP_000854753.1
Coordinates 1903364..1903738 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag JKV47_RS09170 Protein ID WP_001278232.1
Coordinates 1903828..1904196 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV47_RS09135 (1899355) 1899355..1899851 + 497 Protein_1770 type VI secretion system contractile sheath small subunit -
JKV47_RS09140 (1900385) 1900385..1900678 + 294 WP_001110459.1 DUF1778 domain-containing protein -
JKV47_RS09145 (1900675) 1900675..1901163 + 489 WP_000622309.1 GNAT family N-acetyltransferase -
JKV47_RS09150 (1902004) 1902004..1902573 - 570 WP_001290247.1 DUF4942 domain-containing protein -
JKV47_RS09155 (1902670) 1902670..1902867 - 198 WP_000839281.1 DUF957 domain-containing protein -
JKV47_RS09160 (1902879) 1902879..1903367 - 489 WP_000777541.1 DUF5983 family protein -
JKV47_RS09165 (1903364) 1903364..1903738 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
JKV47_RS09170 (1903828) 1903828..1904196 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JKV47_RS09175 (1904359) 1904359..1904580 - 222 WP_000692303.1 DUF987 domain-containing protein -
JKV47_RS09180 (1904643) 1904643..1905119 - 477 WP_001186710.1 RadC family protein -
JKV47_RS09185 (1905131) 1905131..1905301 - 171 Protein_1780 antirestriction protein -
JKV47_RS09190 (1905302) 1905302..1905532 + 231 Protein_1781 integrase core domain-containing protein -
JKV47_RS09195 (1906668) 1906668..1907234 + 567 WP_001126822.1 inovirus-type Gp2 protein -
JKV47_RS09200 (1907492) 1907492..1908064 + 573 WP_000991576.1 hypothetical protein -
JKV47_RS09205 (1908133) 1908133..1908369 + 237 WP_000958152.1 AlpA family transcriptional regulator -
JKV47_RS09210 (1908635) 1908635..1909183 + 549 WP_001167473.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T187496 WP_000854753.1 NZ_CP068680:c1903738-1903364 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T187496 NZ_CP089874:c4647632-4647348 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT187496 WP_001278232.1 NZ_CP068680:c1904196-1903828 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT187496 NZ_CP089874:c4647864-4647622 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References