Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2029841..2030400 Replicon chromosome
Accession NZ_CP068633
Organism Vibrio parahaemolyticus strain VP17

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag JHT19_RS09420 Protein ID WP_005398411.1
Coordinates 2030122..2030400 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag JHT19_RS09415 Protein ID WP_005398409.1
Coordinates 2029841..2030125 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHT19_RS09380 (JHT19_09355) 2025431..2025784 - 354 WP_025555140.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
JHT19_RS09385 (JHT19_09360) 2025922..2026452 - 531 WP_114867632.1 hypothetical protein -
JHT19_RS09390 (JHT19_09365) 2026480..2026572 - 93 WP_114867633.1 DUF3265 domain-containing protein -
JHT19_RS09395 (JHT19_09370) 2026701..2027621 + 921 WP_010446562.1 IS5-like element ISVa2 family transposase -
JHT19_RS09400 (JHT19_09375) 2027912..2028604 + 693 WP_045588479.1 hypothetical protein -
JHT19_RS09405 (JHT19_09380) 2029345..2029704 - 360 WP_228764114.1 hypothetical protein -
JHT19_RS09410 (JHT19_09385) 2029634..2029795 - 162 WP_078581078.1 DUF3265 domain-containing protein -
JHT19_RS09415 (JHT19_09390) 2029841..2030125 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JHT19_RS09420 (JHT19_09395) 2030122..2030400 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JHT19_RS09425 (JHT19_09400) 2030542..2031324 - 783 WP_005462179.1 hypothetical protein -
JHT19_RS09430 (JHT19_09405) 2031481..2032104 - 624 WP_114867634.1 DUF6058 family natural product biosynthesis protein -
JHT19_RS09435 (JHT19_09410) 2032330..2032775 - 446 Protein_1831 GNAT family N-acetyltransferase -
JHT19_RS09440 (JHT19_09415) 2032802..2032894 - 93 WP_079740773.1 DUF3265 domain-containing protein -
JHT19_RS09445 (JHT19_09420) 2032926..2033696 - 771 WP_025787409.1 hypothetical protein -
JHT19_RS09450 (JHT19_09425) 2033849..2034070 - 222 WP_025787410.1 VF530 family protein -
JHT19_RS09455 (JHT19_09430) 2034232..2034309 - 78 WP_080358365.1 DUF3265 domain-containing protein -
JHT19_RS09460 (JHT19_09435) 2034346..2034972 - 627 WP_025510285.1 LysE family translocator -
JHT19_RS09465 2035015..2035131 - 117 WP_100550320.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF 1966183..2026639 60456
- inside Integron - - 2014345..2097853 83508


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T187464 WP_005398411.1 NZ_CP068633:2030122-2030400 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T187464 NZ_CP089849:297257-297583 [Pseudomonas aeruginosa]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCACGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT187464 WP_005398409.1 NZ_CP068633:2029841-2030125 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT187464 NZ_CP089849:296628-297185 [Pseudomonas aeruginosa]
GTGATCTTCAGTGAACAGAAAGTGGCTCACATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCAC
GCTGATCAAACTGCTGTACCTGGCAGACCGAGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTT
CCATGCCCCATGGGCCTGTCCTTTCCTCGACGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGG
ATTTCTCCGTTGGTGGATCACGAGGTCCGTCTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATC
GGATCGCAGCATTTTGGAATCGGTCTGGCAAGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATC
ACATTGGTGAGTGGCACGACCCCCACGGCTCTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGC
GAGGAGCTGGCGGAGATCAAGGCGCGCGATCTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References