Detailed information of TA system TA187157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 549757..550359
• Replicon: chromosome
• Accession: NZ_CP068386
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum strain R51

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: JI728_RS02630
• Protein ID: WP_001159635.1
• Coordinates: 549757..550068 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JI728_RS02635
• Protein ID: WP_000362050.1
• Coordinates: 550069..550359 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI728_RS02595 (544870)	544870..545469	+	600	WP_000965695.1	glucose-1-phosphatase	-
JI728_RS02600 (545463)	545463..546335	+	873	WP_000921423.1	virulence factor BrkB family protein	-
JI728_RS02605 (546332)	546332..546769	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
JI728_RS02610 (546814)	546814..547755	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
JI728_RS02615 (547770)	547770..548216	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
JI728_RS02620 (548213)	548213..548524	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
JI728_RS02625 (548610)	548610..549539	-	930	WP_000171444.1	alpha/beta hydrolase	-
JI728_RS02630 (549757)	549757..550068	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
JI728_RS02635 (550069)	550069..550359	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
JI728_RS02640 (550406)	550406..551335	-	930	WP_000027739.1	formate dehydrogenase accessory protein FdhE	-
JI728_RS02645 (551332)	551332..551964	-	633	WP_020937226.1	formate dehydrogenase cytochrome b556 subunit	-
JI728_RS02650 (551961)	551961..552863	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T187157 WP_001159635.1 NZ_CP068386:549757-550068 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T187157 NZ_CP089778:3192668-3193111 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT187157 WP_000362050.1 NZ_CP068386:550069-550359 [Salmonella enterica subsp. enterica serovar Gallinarum/Pullorum]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT187157 NZ_CP089778:3192424-3192681 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97