187073

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4414709..4415402 Replicon chromosome
Accession NZ_CP068281
Organism Escherichia coli strain CY706

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJW04_RS21480 Protein ID WP_000415584.1
Coordinates 4415106..4415402 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJW04_RS21475 Protein ID WP_000650107.1
Coordinates 4414709..4415104 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW04_RS21465 (4410573) 4410573..4412831 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
JJW04_RS21470 (4412969) 4412969..4414576 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJW04_RS21475 (4414709) 4414709..4415104 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJW04_RS21480 (4415106) 4415106..4415402 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJW04_RS21485 (4415607) 4415607..4416089 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JJW04_RS21490 (4416142) 4416142..4416534 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJW04_RS21495 (4416686) 4416686..4417345 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JJW04_RS21500 (4417342) 4417342..4418691 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJW04_RS21505 (4418737) 4418737..4419069 - 333 WP_000917684.1 DUF2645 family protein -
JJW04_RS21510 (4419388) 4419388..4419969 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJW04_RS21515 (4420000) 4420000..4420314 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T187073 WP_000415584.1 NZ_CP068281:c4415402-4415106 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T187073 NZ_CP089777:1768676-1769080 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT187073 WP_000650107.1 NZ_CP068281:c4415104-4414709 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT187073 NZ_CP089777:1768467-1768670 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References