Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 351180..351966 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag JJN11_RS01640 Protein ID WP_016154457.1
Coordinates 351180..351557 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag JJN11_RS01645 Protein ID WP_009652436.1
Coordinates 351607..351966 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS01610 (JJN11_01610) 346317..347243 - 927 WP_103177927.1 hypothetical protein -
JJN11_RS01615 (JJN11_01615) 347474..348898 + 1425 WP_156653757.1 DUF4832 domain-containing protein -
JJN11_RS01620 (JJN11_01620) 349285..349521 - 237 WP_016154458.1 hypothetical protein -
JJN11_RS01625 (JJN11_01625) 349533..350378 - 846 Protein_314 DUF4942 domain-containing protein -
JJN11_RS01630 (JJN11_01630) 350459..350662 - 204 WP_009652505.1 DUF957 domain-containing protein -
JJN11_RS01635 (JJN11_01635) 350692..351183 - 492 WP_009652438.1 DUF5983 family protein -
JJN11_RS01640 (JJN11_01640) 351180..351557 - 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
JJN11_RS01645 (JJN11_01645) 351607..351966 - 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJN11_RS01650 (JJN11_01650) 351990..352211 - 222 WP_009652392.1 DUF987 domain-containing protein -
JJN11_RS01655 (JJN11_01655) 352225..352707 - 483 WP_016154455.1 DNA repair protein RadC -
JJN11_RS01660 (JJN11_01660) 352719..352937 - 219 WP_009652503.1 hypothetical protein -
JJN11_RS01665 (JJN11_01665) 352948..353421 - 474 WP_009652453.1 antirestriction protein -
JJN11_RS01670 (JJN11_01670) 353438..353692 - 255 WP_009652519.1 hypothetical protein -
JJN11_RS01675 (JJN11_01675) 353692..354510 - 819 WP_009652424.1 DUF932 domain-containing protein -
JJN11_RS01680 (JJN11_01680) 354614..354847 - 234 WP_009652474.1 DUF905 domain-containing protein -
JJN11_RS01685 (JJN11_01685) 354903..355124 - 222 WP_009652443.1 hypothetical protein -
JJN11_RS01690 (JJN11_01690) 355207..355719 - 513 WP_009652395.1 DUF4234 domain-containing protein -
JJN11_RS01695 (JJN11_01695) 355768..356238 - 471 WP_009652431.1 hypothetical protein -
JJN11_RS01700 (JJN11_01700) 356285..356596 - 312 WP_009652410.1 hypothetical protein -
JJN11_RS01705 (JJN11_01705) 356609..356875 - 267 WP_009652486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T186904 WP_016154457.1 NZ_CP068234:c351557-351180 [Leclercia adecarboxylata]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T186904 NZ_CP089774:c2230705-2230145 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT186904 WP_009652436.1 NZ_CP068234:c351966-351607 [Leclercia adecarboxylata]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT186904 NZ_CP089774:c2231043-2230702 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References