Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 71461..72020 Replicon plasmid unnamed1
Accession NZ_CP068153
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag I6I34_RS00435 Protein ID WP_000421259.1
Coordinates 71745..72020 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U0BV64
Locus tag I6I34_RS00430 Protein ID WP_001178090.1
Coordinates 71461..71745 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I34_RS00410 67108..67641 - 534 WP_001372168.1 transcription termination factor NusG -
I6I34_RS00415 68083..68370 - 288 WP_000074855.1 conjugal transfer protein TraA -
I6I34_RS00420 68288..68551 - 264 WP_001749178.1 ash family protein -
I6I34_RS00425 69523..70554 + 1032 WP_022630251.1 replication initiation protein -
I6I34_RS00430 71461..71745 + 285 WP_001178090.1 ribbon-helix-helix domain-containing protein Antitoxin
I6I34_RS00435 71745..72020 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I34_RS00440 72126..72407 + 282 WP_001105066.1 hypothetical protein -
I6I34_RS00445 72599..72865 - 267 WP_000627832.1 hypothetical protein -
I6I34_RS00450 72865..73323 - 459 WP_077738361.1 hypothetical protein -
I6I34_RS00455 73500..74687 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
I6I34_RS00460 74687..75052 - 366 WP_000124098.1 hypothetical protein -
I6I34_RS00465 75244..75846 - 603 WP_000521606.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..80453 80453
- flank IS/Tn - - 73500..74687 1187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T186775 WP_000421259.1 NZ_CP068153:71745-72020 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T186775 NZ_CP089772:1387934-1388365 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10487.94 Da        Isoelectric Point: 6.4613

>AT186775 WP_001178090.1 NZ_CP068153:71461-71745 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMANKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT186775 NZ_CP089772:1387677-1387937 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB A0A7U0BV64

References