Detailed information of TA system TA186769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3174185..3174830
• Replicon: chromosome
• Accession: NZ_CP068152
• Organism: Proteus mirabilis strain FDAARGOS_1079

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: I6I36_RS14675
• Protein ID: WP_004247035.1
• Coordinates: 3174185..3174370 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: I6I36_RS14680
• Protein ID: WP_004247034.1
• Coordinates: 3174417..3174830 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I36_RS14640	3169413..3169640	+	228	WP_004247042.1	YejL family protein	-
I6I36_RS14645	3169664..3171397	+	1734	WP_012367752.1	LPS biosynthesis-modulating metalloenzyme YejM	-
I6I36_RS14655	3171815..3172090	+	276	WP_049208653.1	hypothetical protein	-
I6I36_RS14660	3172194..3172745	+	552	WP_049208654.1	PH domain-containing protein	-
I6I36_RS14665	3172858..3173010	-	153	WP_155289810.1	hypothetical protein	-
I6I36_RS14670	3173304..3174074	-	771	Protein_2848	DUF1073 domain-containing protein	-
I6I36_RS14675	3174185..3174370	+	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6I36_RS14680	3174417..3174830	+	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6I36_RS14685	3174926..3175426	+	501	WP_041707083.1	response regulator	-
I6I36_RS14690	3175740..3176033	+	294	Protein_2852	LysE family transporter	-
I6I36_RS14695	3176146..3176724	-	579	WP_071233580.1	alpha/beta hydrolase	-
I6I36_RS14700	3177574..3178320	+	747	WP_049203051.1	methyltransferase domain-containing protein	-
I6I36_RS14705	3178489..3178665	-	177	WP_004247793.1	hypothetical protein	-
I6I36_RS14710	3179117..3179275	+	159	WP_004247025.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3165074..3177572	12498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T186769 WP_004247035.1 NZ_CP068152:3174185-3174370 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T186769 NZ_CP089772:c757692-757255 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT186769 WP_004247034.1 NZ_CP068152:3174417-3174830 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT186769 NZ_CP089772:c757943-757689 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85