Detailed information of TA system TA186766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 723931..725502
• Replicon: chromosome
• Accession: NZ_CP068152
• Organism: Proteus mirabilis strain FDAARGOS_1079

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: I6I36_RS03455
• Protein ID: WP_012368637.1
• Coordinates: 724189..725502 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: I6I36_RS03450
• Protein ID: WP_004249771.1
• Coordinates: 723931..724188 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I36_RS03425	719893..720036	+	144	WP_004246509.1	50S ribosomal protein L34	-
I6I36_RS03430	720054..720413	+	360	WP_004246510.1	ribonuclease P protein component	-
I6I36_RS03435	720377..720637	+	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
I6I36_RS03440	720640..722280	+	1641	WP_004246512.1	membrane protein insertase YidC	-
I6I36_RS03445	722418..723782	+	1365	WP_151250855.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
I6I36_RS03450	723931..724188	+	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
I6I36_RS03455	724189..725502	+	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I36_RS03460	725905..726369	+	465	WP_004249773.1	DUF1097 domain-containing protein	-
I6I36_RS03465	726554..727483	+	930	WP_201704618.1	metallophosphoesterase	-
I6I36_RS03470	727515..729476	+	1962	WP_004249953.1	hypothetical protein	-
I6I36_RS03475	729530..730333	-	804	WP_049217837.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T186766 WP_012368637.1 NZ_CP068152:724189-725502 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T186766 NZ_CP089772:c755287-754904 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT186766 WP_004249771.1 NZ_CP068152:723931-724188 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT186766 NZ_CP089772:c755537-755382 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9