Detailed information of TA system TA186579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1937167..1937774
• Replicon: chromosome
• Accession: NZ_CP068060
• Organism: Streptococcus anginosus strain FDAARGOS_1155

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: I6J12_RS09295
• Protein ID: WP_003038349.1
• Coordinates: 1937167..1937358 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0S7P0
• Locus tag: I6J12_RS09300
• Protein ID: WP_003038371.1
• Coordinates: 1937394..1937774 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J12_RS09250	1932476..1932643	+	168	WP_003038324.1	hypothetical protein	-
I6J12_RS09255	1932986..1933264	+	279	WP_003027794.1	hypothetical protein	-
I6J12_RS09260	1933261..1933437	+	177	WP_003027795.1	hypothetical protein	-
I6J12_RS09265	1933427..1933663	+	237	WP_003038392.1	hypothetical protein	-
I6J12_RS09270	1933660..1933995	+	336	WP_003038362.1	hypothetical protein	-
I6J12_RS09275	1933997..1934266	+	270	WP_003038376.1	hypothetical protein	-
I6J12_RS09280	1934275..1935081	+	807	WP_003038339.1	phage replisome organizer N-terminal domain-containing protein	-
I6J12_RS09285	1935096..1935947	+	852	Protein_1824	ATP-binding protein	-
I6J12_RS09290	1936196..1936636	+	441	WP_003038422.1	ArpU family transcriptional regulator	-
I6J12_RS09295	1937167..1937358	+	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6J12_RS09300	1937394..1937774	+	381	WP_003038371.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6J12_RS09305	1938326..1938766	+	441	WP_003032335.1	LytTR family transcriptional regulator	-
I6J12_RS09310	1938763..1939221	+	459	WP_003038399.1	DUF3021 domain-containing protein	-
I6J12_RS09315	1939409..1941970	-	2562	WP_042752943.1	DNA mismatch repair protein MutS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1917879..1937774	19895

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T186579 WP_003038349.1 NZ_CP068060:1937167-1937358 [Streptococcus anginosus]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T186579 NZ_CP089610:721439-721846 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14150.14 Da
• Isoelectric Point: 4.5235

>AT186579 WP_003038371.1 NZ_CP068060:1937394-1937774 [Streptococcus anginosus]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAVRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT186579 NZ_CP089610:721182-721442 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Toxin

• AlphaFold DB: I0S7M8

Antitoxin

• AlphaFold DB: I0S7P0