Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 107868..108294 | Replicon | plasmid pXJW9B277-F18 |
| Accession | NZ_CP068043 | ||
| Organism | Escherichia coli strain XJW9B277 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | JJE78_RS25435 | Protein ID | WP_001372321.1 |
| Coordinates | 107868..107993 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 108070..108294 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJE78_RS25410 (103242) | 103242..103931 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| JJE78_RS25415 (104118) | 104118..104501 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| JJE78_RS25420 (104822) | 104822..105424 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| JJE78_RS25425 (105721) | 105721..106542 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| JJE78_RS25430 (106660) | 106660..106947 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| JJE78_RS26520 (106972) | 106972..107178 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| JJE78_RS26525 (107248) | 107248..107420 | + | 173 | Protein_129 | hypothetical protein | - |
| JJE78_RS26530 (107418) | 107418..107648 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| JJE78_RS25435 (107868) | 107868..107993 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| JJE78_RS26535 (107935) | 107935..108084 | - | 150 | Protein_132 | plasmid maintenance protein Mok | - |
| - (108070) | 108070..108294 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (108070) | 108070..108294 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (108070) | 108070..108294 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (108070) | 108070..108294 | - | 225 | NuclAT_0 | - | Antitoxin |
| JJE78_RS25440 (108106) | 108106..108294 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| JJE78_RS25445 (108263) | 108263..109025 | - | 763 | Protein_134 | plasmid SOS inhibition protein A | - |
| JJE78_RS25450 (109022) | 109022..109456 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| JJE78_RS25455 (109511) | 109511..109708 | - | 198 | Protein_136 | hypothetical protein | - |
| JJE78_RS25460 (109736) | 109736..109969 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| JJE78_RS25465 (110037) | 110037..110576 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| JJE78_RS25470 (110602) | 110602..110808 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| JJE78_RS26540 (110878) | 110878..110958 | + | 81 | Protein_140 | hypothetical protein | - |
| JJE78_RS26545 (111141) | 111141..111310 | - | 170 | Protein_141 | hypothetical protein | - |
| JJE78_RS25475 (111947) | 111947..112918 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(A) / floR / sul2 / aph(4)-Ia / aac(3)-IVa / blaCTX-M-14 / fosA3 / tet(A) / qacE / aadA2 / dfrA12 / blaTEM-1B / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..133299 | 133299 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T186555 WP_001372321.1 NZ_CP068043:c107993-107868 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T186555 NZ_CP089599:c59473-59162 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
Antitoxin
Download Length: 225 bp
>AT186555 NZ_CP068043:c108294-108070 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
