186244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1627218..1627740 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag JJB81_RS07955 Protein ID WP_000221343.1
Coordinates 1627218..1627502 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag JJB81_RS07960 Protein ID WP_000885424.1
Coordinates 1627492..1627740 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS07935 (1623293) 1623293..1624801 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
JJB81_RS07940 (1624846) 1624846..1625334 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
JJB81_RS07945 (1625527) 1625527..1626606 + 1080 WP_210138940.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
JJB81_RS07950 (1626658) 1626658..1627047 - 390 WP_000194089.1 RidA family protein -
JJB81_RS07955 (1627218) 1627218..1627502 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJB81_RS07960 (1627492) 1627492..1627740 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JJB81_RS07965 (1627892) 1627892..1628107 + 216 WP_000206207.1 hypothetical protein -
JJB81_RS07970 (1628097) 1628097..1628429 + 333 WP_000253154.1 DUF1493 family protein -
JJB81_RS07975 (1628572) 1628572..1629480 + 909 WP_010989018.1 hypothetical protein -
JJB81_RS07980 (1629536) 1629536..1630250 - 715 Protein_1563 helix-turn-helix domain-containing protein -
JJB81_RS07985 (1631058) 1631058..1632524 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T186244 WP_000221343.1 NZ_CP067397:c1627502-1627218 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T186244 NZ_CP089302:1088157-1088525 [Bifidobacterium longum]
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
GAAGCCGCGTCCGGTGGTTATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGTGACGTGCCGCTGCTCGACTGGAAGGCCGAGGGGCTGTTGAAGCCGTCACTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT186244 WP_000885424.1 NZ_CP067397:c1627740-1627492 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT186244 NZ_CP089302:1087892-1088176 [Bifidobacterium longum]
ATGGGTAAGCTGGTAGCCAATATCGATGATGATATCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCCGTCAACATGTTCCTACGCCAGTCTCTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCGG
ACGGTTATCCGGTGCCGCCTGTTCACAATGCATACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGGATGATTCGGAGGATGATGTCTATGACCAGTACGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References