Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4109726..4110363 Replicon chromosome
Accession NZ_CP067101
Organism Bradyrhizobium diazoefficiens strain 41_2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJB98_RS19435 Protein ID WP_200457694.1
Coordinates 4109726..4110124 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JJB98_RS19440 Protein ID WP_200455072.1
Coordinates 4110121..4110363 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB98_RS19410 4105148..4105366 + 219 WP_200455067.1 hypothetical protein -
JJB98_RS19415 4105381..4106526 - 1146 WP_200455068.1 tRNA guanosine(34) transglycosylase Tgt -
JJB98_RS19420 4106760..4107506 + 747 WP_200455069.1 TetR/AcrR family transcriptional regulator -
JJB98_RS19425 4107759..4108349 + 591 WP_200455070.1 PepSY domain-containing protein -
JJB98_RS19430 4108581..4109618 + 1038 WP_200455071.1 aspartate-semialdehyde dehydrogenase -
JJB98_RS19435 4109726..4110124 - 399 WP_200457694.1 type II toxin-antitoxin system VapC family toxin Toxin
JJB98_RS19440 4110121..4110363 - 243 WP_200455072.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JJB98_RS19445 4110420..4111493 - 1074 WP_200455073.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
JJB98_RS19450 4111614..4112078 - 465 WP_200455074.1 peptidylprolyl isomerase -
JJB98_RS19455 4112075..4112500 - 426 WP_200455075.1 hypothetical protein -
JJB98_RS19460 4112509..4113072 - 564 WP_200455076.1 peptidylprolyl isomerase -
JJB98_RS19465 4113109..4113606 - 498 WP_200455077.1 pantetheine-phosphate adenylyltransferase -
JJB98_RS19470 4113865..4114122 + 258 WP_200455078.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4099955..4110363 10408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Antitoxin VapB-like

(2-79)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14021.17 Da        Isoelectric Point: 4.5759

>T185761 WP_200457694.1 NZ_CP067101:c4110124-4109726 [Bradyrhizobium diazoefficiens]
MMVLDTSAIIATVTNEPDGQRYRTAMLDADSLSMSAIAVLETKIVLSARFGSAAVTFFDELLATAGIIVVPFDDDMAKSA
FEAFQRFGKGGGHPAQLNIVDCAVYALAKARSQPLLFKGADFARTDVVVALT

Download         Length: 399 bp

>T185761 NZ_CP089021:c2803635-2802313 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCTCTCTCACTGCCGCTGCAGTATGGCAATATCACGG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAA
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTTACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8906.05 Da        Isoelectric Point: 4.8146

>AT185761 WP_200455072.1 NZ_CP067101:c4110363-4110121 [Bradyrhizobium diazoefficiens]
MNIRSAKVDELVQRLARLTGEDIETALERAIEERLSRIGSPVADRRAALTSFFERTASLPVVDSRSADEILGYDRFGLPS

Download         Length: 243 bp

>AT185761 NZ_CP089021:c2803901-2803635 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References