Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 725435..726101 Replicon chromosome
Accession NZ_CP066794
Organism Erwinia amylovora strain 17-2187

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag JGC41_RS03325 Protein ID WP_004161808.1
Coordinates 725682..726101 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag JGC41_RS03320 Protein ID WP_004155593.1
Coordinates 725435..725701 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC41_RS03300 721945..722637 + 693 WP_004155586.1 SDR family oxidoreductase -
JGC41_RS03305 722742..723350 - 609 WP_004155587.1 HD domain-containing protein -
JGC41_RS03310 723563..724222 + 660 WP_004155588.1 hemolysin III family protein -
JGC41_RS03315 724223..725209 - 987 WP_004155590.1 tRNA-modifying protein YgfZ -
JGC41_RS03320 725435..725701 + 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
JGC41_RS03325 725682..726101 + 420 WP_004161808.1 hypothetical protein Toxin
JGC41_RS03330 726219..726737 - 519 WP_004155596.1 flavodoxin FldB -
JGC41_RS03335 726967..727920 - 954 WP_004155597.1 DMT family transporter -
JGC41_RS03340 728430..730109 - 1680 WP_004155599.1 type III effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T185029 WP_004161808.1 NZ_CP066794:725682-726101 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T185029 NZ_CP087880:2554303-2554521 [Pseudocitrobacter corydidari]
ATGTCTGAGAAACCATTAACTAAAACGGATTATTTGATGCGACTGCGCCGTTGCCAGTCAATTGATACGCTGGAACGCGT
CATTGAAAAAAATAAATATGAACTTTCTGACAATGAACTGGCGGTATTTTACTCAGCTGCCGATCATCGTCTGGCTGAAT
TGACGATGAATAAGCTGTACGACAAGATCCCATCTACCGTCTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT185029 WP_004155593.1 NZ_CP066794:725435-725701 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT185029 NZ_CP087880:2553902-2554276 [Pseudocitrobacter corydidari]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAACTCAGATTCCTCTGCGAAACGCTCTATCATGACTGCCTCGC
CAATCTTGAAGAGAGTAACCATGGTTGGGTTAATGACCCCTCCTCGGCTATCAATCTTCAACTTAATGAGCTGATCGAGC
ATATCGCAACCTTTGCGCTTAATTATAAAATTAAGTACAACGAAGATAATAAATTGATTGCACAAATTGACGAATATCTG
GATGATACTTTCATGTTGTTCAGTAACTACGGCATAAATAGTGAAGACTTGCAAAAATGGCGCAAGTCCGGGAACAAACT
CTTCCGCTGTTTCGTCAATGCCAGCCGGGCTAACCCTGTTAGTCTCTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References