Detailed information of TA system TA184681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1700722..1701203
• Replicon: chromosome
• Accession: NZ_CP066558
• Organism: Histophilus somni strain ASc-MMNZ-VFA-070

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFL49_RS07800
• Protein ID: WP_075294307.1
• Coordinates: 1700943..1701203 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL49_RS07795
• Protein ID: WP_075294306.1
• Coordinates: 1700722..1700943 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL49_RS07790	1698367..1700286	-	1920	WP_075294305.1	transferrin-binding protein-like solute binding protein	-
JFL49_RS07795	1700722..1700943	+	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
JFL49_RS07800	1700943..1701203	+	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFL49_RS07805	1701207..1701317	-	111	Protein_1508	CAAX protease	-
JFL49_RS07810	1701381..1702832	-	1452	WP_075294308.1	DUF560 domain-containing protein	-
JFL49_RS07815	1702948..1703139	-	192	WP_075294309.1	hypothetical protein	-
JFL49_RS07820	1703318..1703737	-	420	WP_075294310.1	pseudouridine synthase	-
JFL49_RS07825	1703803..1705143	-	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1698367..1714257	15890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T184681 WP_075294307.1 NZ_CP066558:1700943-1701203 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184681 NZ_CP087771:c1587491-1587249 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT184681 WP_075294306.1 NZ_CP066558:1700722-1700943 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184681 NZ_CP087771:c1587259-1587002 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA