Detailed information of TA system TA184680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 826547..827146
• Replicon: chromosome
• Accession: NZ_CP066558
• Organism: Histophilus somni strain ASc-MMNZ-VFA-070

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: JFL49_RS04135
• Protein ID: WP_012340732.1
• Coordinates: 826841..827146 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFL49_RS04130
• Protein ID: WP_075294500.1
• Coordinates: 826547..826837 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFL49_RS04100	822390..822851	-	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-
JFL49_RS04105	823040..823492	-	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
JFL49_RS04110	823775..824695	+	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
JFL49_RS04115	824742..825185	+	444	WP_012340735.1	NfeD family protein	-
JFL49_RS04120	825195..825815	+	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
JFL49_RS04125	825812..826375	+	564	WP_178384292.1	molecular chaperone	-
JFL49_RS04130	826547..826837	+	291	WP_075294500.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFL49_RS04135	826841..827146	+	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
JFL49_RS04140	827367..827603	+	237	WP_080514392.1	recombinase family protein	-
JFL49_RS04145	827587..828708	-	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
JFL49_RS04150	828849..830900	+	2052	WP_075294501.1	methionine--tRNA ligase	-
JFL49_RS04155	830936..831796	-	861	WP_075294502.1	RNase adapter RapZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T184680 WP_012340732.1 NZ_CP066558:826841-827146 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T184680 NZ_CP066558:826841-827146 [Histophilus somni]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10832.18 Da
• Isoelectric Point: 4.2845

>AT184680 WP_075294500.1 NZ_CP066558:826547-826837 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLVQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT184680 NZ_CP066558:826547-826837 [Histophilus somni]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGTTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Structures

Toxin

• AlphaFold DB: B0UV74