Detailed information of TA system TA184621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2339243..2340831
• Replicon: chromosome
• Accession: NZ_CP066543
• Organism: Klebsiella pneumoniae strain BTS

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0H3GN97
• Locus tag: D6T75_RS12435
• Protein ID: WP_004199851.1
• Coordinates: 2339509..2340831 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: D6T75_RS12430
• Protein ID: WP_002904790.1
• Coordinates: 2339243..2339509 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D6T75_RS12405	2334393..2335316	+	924	WP_004199849.1	LysR family hpxDE operon transcriptional regulator HpxR	-
D6T75_RS12410	2335297..2336451	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
D6T75_RS12415	2336797..2338176	+	1380	WP_004199850.1	purine permease	-
D6T75_RS12420	2338154..2338654	+	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
D6T75_RS12425	2338651..2338977	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
D6T75_RS12430	2339243..2339509	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
D6T75_RS12435	2339509..2340831	+	1323	WP_004199851.1	type II toxin-antitoxin system HipA family toxin	Toxin
D6T75_RS12440	2340848..2342140	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
D6T75_RS12445	2342273..2343277	-	1005	WP_004199852.1	type 1 fimbrial protein	-
D6T75_RS12450	2343265..2345766	-	2502	WP_004199853.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49128.44 Da
• Isoelectric Point: 7.2487

>T184621 WP_004199851.1 NZ_CP066543:2339509-2340831 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T184621 NZ_CP087705:1296124-1296426 [Halopseudomonas aestusnigri]
ATGGCTGAGGTAATCTGGACAGAGCCTGCAGTTCAAGACCTTGACTCCATCGCTGAGTATATTGCTTTGGATAACCCGGC
CGCCGCACGCGAGCTGGTGCAAGAGGTGTTCGACAAGATCGAGCGTTTGGGAATATTTCCTCAGTCCGGTCGAGTTCCGC
CTGAGCTTCCCAACTCGGTATACAGGGAGGTAGTGGTCTCACCGTGCCGTATTTTTTATCGTGAGGACGAAAAACGGGTT
CTGGTACTTTGCGTCATGCGCGAGGAGCGGCAGCTGCGTGCGTTTATGCTTGGACACGGTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT184621 WP_002904790.1 NZ_CP066543:2339243-2339509 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT184621 NZ_CP087705:1295879-1296136 [Halopseudomonas aestusnigri]
ATGAAAGTCGAGCTTGTTACTAACCTAAAACGTCAGGCGACAAGGATTCTGGCAGATCTCCACATGTCGAAAGAGCCGGT
GCTGATAACCGAGCATGGCAAACCATCCGCATACTTGGTGGACGTGCAGGATTACGAGTTTATGCAGCGCCGTATTGAGC
TGCTTGAAGGTCTCTCGCGTGGGGAGCGAGCTGTACTCGAGGGAAGGACTTACAGCCAGCGCGAGGCCAGAGAGAAAATG
AGCAAATGGCTGAGGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GN97

Antitoxin

• AlphaFold DB: A0A0H3GXD8