Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1397816..1398458 Replicon chromosome
Accession NZ_CP066194
Organism Bacillus cytotoxicus strain E8.1

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag JC776_RS06900 Protein ID WP_000635963.1
Coordinates 1397816..1398166 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8PTJ6
Locus tag JC776_RS06905 Protein ID WP_000004571.1
Coordinates 1398171..1398458 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC776_RS06885 (JC776_06885) 1394524..1394988 - 465 WP_011983367.1 SprT family protein -
JC776_RS06890 (JC776_06890) 1395375..1395509 + 135 WP_087094358.1 cortex morphogenetic protein CmpA -
JC776_RS06895 (JC776_06895) 1395583..1397751 - 2169 WP_048721313.1 Tex family protein -
JC776_RS06900 (JC776_06900) 1397816..1398166 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JC776_RS06905 (JC776_06905) 1398171..1398458 - 288 WP_000004571.1 antitoxin EndoAI Antitoxin
JC776_RS06910 (JC776_06910) 1398672..1399841 - 1170 WP_011983365.1 alanine racemase -
JC776_RS06915 (JC776_06915) 1399963..1400913 - 951 WP_041810183.1 outer membrane lipoprotein carrier protein LolA -
JC776_RS06920 (JC776_06920) 1401069..1401428 - 360 WP_011983363.1 holo-ACP synthase -
JC776_RS06925 (JC776_06925) 1401519..1402079 + 561 WP_048721301.1 rhomboid family intramembrane serine protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-113)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T184160 WP_000635963.1 NZ_CP066194:c1398166-1397816 [Bacillus cytotoxicus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T184160 NZ_CP087392:333509-334396 [Pectobacterium parvum]
ATGCTGAAGCAACAAATTCGCCAAATTGTCCAGTCAAACCCTGACTATGCCGCAGTGACACCCGTCATAGAAAAAGAGAT
CTTGCATCATGACATTATGGATGTGCTGATCAAACAGGGCGTCATGCAGCGGTTAACGTTCATTGGCGGCACCTCATTAC
GAATGTGTTACAACAGCAGCAGGCTATCAGAAGATCTTGATTTCAATGGTGGTCATGATTTCAAGCCCTCAGCGTTTGAG
GGGCTGGAGTCCGAAATCCAAACCTATATTCAGAACAAGTATGAAACCGAGGTTTGGGTAAACAAACCTTCTGGCGAGCA
GCAAGGGGATACCGTTTCTTGGAAAATTAGTATCGTAAAAGAAGCTAATCGTCCTGATTTTCCTCGGCAAAAAATGCATA
TTGACGTCTGTGCTATTCCGTCATTTGATATTGAAAAGCGCCCGCTAATCAATCATTACGACATTGTTGTACCGACTGAA
GGGATCTTGGTTCCGGTACAGTCGTTACAAGAAACATTGGCTGATAAGCTGATCGCGTTAGCGTATCGGGCAAGACGTAT
TAAACCTCGTGATATCTGGGATATTATTTGGATTAAGCAGCGCGGTATTGATTTATCCAAGACACTGGTTGAAAAGAAGC
TCACCGCCAGACAGAAGCAAATAGAAGACTTTCGACAGGCGTTGTCTATTCAGTTAGCCAAGCTAATGTCGGAAGATGAA
GTCCGTGACGACTTCAATATGGAAATGAGCCGCTTTATCCCTAAGCCAATTAAAGAGAGAACTCTCGATAATCCTGAATA
TTGGGCTTATGTTCAAGGCGAGGTGCATGCCATCGCGTCTGAGTTACTGAATGACGGAATACCAAAAAATCCATTTGATA
TGGGTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10748.30 Da        Isoelectric Point: 8.9605

>AT184160 WP_000004571.1 NZ_CP066194:c1398458-1398171 [Bacillus cytotoxicus]
VSESSVTTEIVVRLPKQVVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT184160 NZ_CP087392:332956-333480 [Pectobacterium parvum]
ATGGCTAAATCTGATGAGCTATTAAACGCGTTGGCCAAAGCAGTGAACGCCGGTGGCGGCATTCACAGTGTAACAGAGCT
GGCTTTTATGCAGGGTGTGCCTTGTGACTCAGCCTTTAGAAAATTCCTGGCAGATTGCGTAAAGAAGGGGTTGCTAAGAC
GAGTGGTGAAAGGCTTCTATGAAAGTGTTATTACACCACCTGAGCCTGAGACTGCCATTTATAAAATCATCAAAAAGTTG
CGCAGCAGCGTATTGAGCTACATCAGCTTAGAAAGTCAGCTCAGTCATACCGGTGATATTTCACAAGTTGTGATGGGTAG
AGTCACTGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAGTTTACCCATACTAAAAAGC
CAGTCGAGCAAATTGCACCTAATTTGTATTATGACCCCGACATCAAAATGTATCGCGCATACAAGGAACAAGCGATTGCA
GATCTAAAACACTGCCAGCGCAATCTACATATGTTGGAGAGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY


Antitoxin

Source ID Structure
AlphaFold DB R8PTJ6

References