Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4419567..4420402 Replicon chromosome
Accession NZ_CP066144
Organism Escherichia coli strain ZLWT

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag ICI43_RS21175 Protein ID WP_000854759.1
Coordinates 4419567..4419944 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag ICI43_RS21180 Protein ID WP_001295723.1
Coordinates 4420034..4420402 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI43_RS21150 4415678..4417318 - 1641 WP_001332039.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -
ICI43_RS21155 4418091..4418267 - 177 Protein_4147 helix-turn-helix domain-containing protein -
ICI43_RS21160 4418631..4418789 - 159 WP_001467148.1 hypothetical protein -
ICI43_RS21165 4418889..4419065 - 177 WP_000839286.1 DUF957 domain-containing protein -
ICI43_RS21170 4419082..4419570 - 489 WP_000761690.1 hypothetical protein -
ICI43_RS21175 4419567..4419944 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
ICI43_RS21180 4420034..4420402 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ICI43_RS21185 4420565..4420786 - 222 WP_000692345.1 DUF987 domain-containing protein -
ICI43_RS21190 4420849..4421325 - 477 WP_001186775.1 RadC family protein -
ICI43_RS21195 4421341..4421814 - 474 WP_001350782.1 antirestriction protein -
ICI43_RS21200 4422156..4422974 - 819 WP_001234738.1 DUF945 domain-containing protein -
ICI43_RS21205 4423129..4423287 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4408026..4434938 26912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T184081 WP_000854759.1 NZ_CP066144:c4419944-4419567 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T184081 NZ_CP087328:c2660450-2659794 [Acinetobacter baumannii]
ATGGTTGGACGTAATTATAGTGATGTACTCAATCCGCAAAAGGCATTGATTTGGCGTATTGTGCATCGTGATAATATTCC
GTGGATATTAGAAAATGGCTTACATAGCAGTAATAGTCCAACACAATGTGTAAATTGGGTTCAGATTGGCAGTCCAGAAC
TGATTGAGAAAAGACAACTGCATCCTGTTCCTGTAGGGAAAAAGGGTGTGCTAAGTGACTATATTCCATTTTATTTCACA
CCATTTTCACCTATGCTGCTGAATATAAAGAGTGGCCGTGGCGGTGTACGTCAGCGTACTAATGATGAAATTGTTATTTT
AGTTTCTAGTTTGTATCAGCTACAGCAGCAGCAAATTCCTTTTGTTTTTACAAATAGTCATGCCTATTACCAATGGGCTG
AATTCTATACAGATTTATCTAGCTTAAATGAGATCGATTGGTCAATATTACAGGCAAGAGATTTTAAAAGAGATATGGAT
GATCCTGCGAAGTTTGAACGTTATCAAGCCGAAGCGTTAGTTCATCAACACTGCCCAACAAAAGTATTGATTGGGGTGAT
ATGTTATACTGAAACAGTTAAAGCTCAAATAGAACAGTGGCTGCAACAAGCAGATGTTAATATTCCTGTGCATGTGAGAC
AAGGGGTGTATTTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT184081 WP_001295723.1 NZ_CP066144:c4420402-4420034 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT184081 NZ_CP087328:c2659794-2658709 [Acinetobacter baumannii]
ATGATTCGTTATACAACAGGAAACTTATTAGATGCTCCTGTAGAAGCATTGGTAAATACCGTGAATACCGTTGGTGTAAT
GGGTAAAGGTATTGCTTTAATGTTTAAGGAGCGTTTTCCAAAAAACATGGCAGCTTATAGTCAAGCGTGCAAAGCTGGAC
AGGTTACAACTGGAAAAATGTTTGTGACTGAAACTAATGAGTTAATGGGCGCACGTTGGATTATTAACTTTCCAACTAAA
CAGCATTGGCGGGATAAATCCAAACTCCAATGGATTGAAGATGGTTTGCAGGATCTTAAAAAGTTCATCATTGATCATCA
AGTTAAATCTATTGCAATTCCACCATTAGGTGCGGGTAATGGTGGGTTAGAGTGGAGTCGTGTTAAATCAAAAATTGAGA
CAGAATTATCCGATTTAGAGTATGTGGATATTTTGATTTTTGAACCAACCACACAGTATCAAAACGTGGCAAAGAAAATA
GGTGTATCACAACTTACACCAGCACGAGCCATGATTGCAGAGTTAGTACGTCGTTATTGGGTATTGGGGATTGAATGTAG
TCTATTAGAAATCCAAAAACTGGCATGGTTTTTACAGCGAGTTATTGAGCAAAAACAATTACCAAATGAATTGAAGCTTA
ATTTTCAGGCGAACTATTATGGTCCTTATGCTTCTAATTTAGACCATTTGTTGAATGCAATGGATGGTAGCTATCTCAAA
TCGGACAAGCGAATTCCTGATTGTGACCCCTTAGATGTGATTTGGTTCAATGATCAGCAAAAAAGTAAAGTTCAAGGTTA
TCTGATTAGTGAAGCAAAAGAGTATATGGCTGCTGTAGAAGGAGCTGCAACATTGATAGAGGGTTTTGAATCACCATTTG
GTATGGAGCTTTTGGCAACAGTAGATTGGCTTATCTATAAGGAAGGTTATCAACCTAATGTTGAATCAATTCAAGAAGGG
TTAGCGAATTGGAGTGCAGGTGAGCGTTGGGCAAGACGGAAATCTGATTTATTCAAAGCAGAGCATATTCAATTTGCATT
ACAAAAATTAGATGGTTTTGCTTATTCTTATTCAGATGTAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References