Detailed information of TA system TA183886

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1866157..1866415
• Replicon: chromosome
• Accession: NZ_CP066085
• Organism: Escherichia fergusonii strain FDAARGOS_1032

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6H89_RS09035
• Protein ID: WP_000809168.1
• Coordinates: 1866157..1866309 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1866358..1866415 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H89_RS09015	1861223..1861810	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
I6H89_RS09020	1861844..1862410	-	567	WP_000528529.1	acetate uptake transporter	-
I6H89_RS09025	1862918..1864834	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6H89_RS09030	1864923..1866053	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6H89_RS09035	1866157..1866309	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1866358..1866415	+	58	-	-	Antitoxin
I6H89_RS09040	1866850..1868016	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
I6H89_RS09045	1868084..1868983	+	900	WP_000019049.1	transcriptional activator NhaR	-
I6H89_RS09050	1869079..1869342	-	264	WP_001274021.1	30S ribosomal protein S20	-
I6H89_RS09055	1869445..1869663	+	219	WP_012599853.1	DUF2575 family protein	-
I6H89_RS09060	1869671..1870612	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T183886 WP_000809168.1 NZ_CP066085:c1866309-1866157 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T183886 NZ_CP087201:c1549364-1549080 [Pseudomonas sp. B21-059]
ATGCGCATTGAATGGCTACGCAGCGCCCTGAACAACCTGGACGCTGAGGCCCGTCATATCGCCCAGGACGATCCCCGGGC
CGCCGGGGAATTTGTCAGGGCGCTGTTGATCAGTATCGAGCAACTGGCCCGGTTCCCCTCAAGTGGCCGCGAAGGCCGCC
TGCCCGGCACCCGGGAATGGGTAGTGCCGGGCTGGCCTTACCTGATTCCCTACCGGGTGCGCGGGGACCGGCTACAGATT
CTGCGAATTTTCCATACCCGCCGTCAGCCCCCGGCACGTTGGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT183886 NZ_CP066085:1866358-1866415 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin