Detailed information of TA system TA183838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 574247..574850
• Replicon: chromosome
• Accession: NZ_CP066057
• Organism: Moraxella nonliquefaciens strain FDAARGOS_1006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6H63_RS03005
• Protein ID: WP_062498575.1
• Coordinates: 574521..574850 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1B8Q5Z3
• Locus tag: I6H63_RS03000
• Protein ID: WP_062498565.1
• Coordinates: 574247..574528 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H63_RS02975	569791..570402	+	612	WP_066888959.1	shikimate kinase	-
I6H63_RS02980	570470..571573	+	1104	WP_066892204.1	3-dehydroquinate synthase	-
I6H63_RS02985	571638..572669	+	1032	WP_145916063.1	hypothetical protein	-
I6H63_RS02990	572719..573342	+	624	WP_066888871.1	carbonic anhydrase	-
I6H63_RS02995	573458..573991	+	534	WP_066888869.1	lactoylglutathione lyase	-
I6H63_RS03000	574247..574528	-	282	WP_062498565.1	helix-turn-helix domain-containing protein	Antitoxin
I6H63_RS03005	574521..574850	-	330	WP_062498575.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H63_RS03010	574907..575812	-	906	WP_158512481.1	hypothetical protein	-
I6H63_RS03015	575712..576059	-	348	WP_158512482.1	hypothetical protein	-
I6H63_RS03020	576157..576426	+	270	WP_082995448.1	helix-turn-helix transcriptional regulator	-
I6H63_RS03030	576674..577219	+	546	WP_066888863.1	cytochrome c5 family protein	-
I6H63_RS03035	577383..578321	+	939	WP_066892087.1	ABC transporter ATP-binding protein	-
I6H63_RS03040	578360..579130	+	771	WP_067008211.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (17-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12549.41 Da
• Isoelectric Point: 9.7810

>T183838 WP_062498575.1 NZ_CP066057:c574850-574521 [Moraxella nonliquefaciens]
MTFIETSIFTKAIKELFDDDEYRKIQNELLNDPQKGDLIQGTGGLRKIRFGRNSGKSSGVRILYYYTDEFGRIYLFAVYP
KSVKDNITNAEKAVFKTLITILKQELKNG

Nucleotide

• Length: 330 bp

>T183838 NZ_CP087189:c2639611-2639360 [Pseudomonas protegens]
GTGTCCAAGAACGATAAGCTTCTCGCCAAGTTACTCAACGACCGAGGGACCTTTTCCTGGCAGGAACTGGTCACTCTCCT
AAAGCGCCTGGGCTACACACCGTTGGAGGGCTCGGGCAGCCGGGTAAAATTCGACAATGGTGATCCAGGCGCAATGATCA
ACCTGCACAAACCGCACCCCGGTAATGAGCTGAAGGCCTACATACGCCGCCAAGTGATCGAGCAACTGAAATCGGGAGGT
CTCATACCGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10452.10 Da
• Isoelectric Point: 10.2029

>AT183838 WP_062498565.1 NZ_CP066057:c574528-574247 [Moraxella nonliquefaciens]
MDKQLFDDIVASMNEAIAITKGEIAPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLRNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT183838 NZ_CP087189:c2639363-2639022 [Pseudomonas protegens]
GTGAACAACCTACTGCAGCACAAGGGCTATTACGGCTCTATCGAGGTCAGTACCGAGGACAATTGCCTCTTTGGCAAACT
TCAGTTCATAAGGGCCTTGGTTAGCTATGAGGGGCAGACCGTGGCTGAACTCGAAGCGGCCTTCAAAGAGGCAGTAGACG
ACTATCTGGATACCTGTGAGCAATCGGGTACAGCACCCGAAATCCCTTGCAAAGGCTCGTTCAACGTTCGGGTAGGCCAC
GATCTTCATCTAGCGGCTGCCGTGGCCGCCACCCGGCAGAATGTATCGTTGAACGATCTGACTCGTCAGGCCCTGAATGA
ATACCTGCAACATCACGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B8Q5Z3