Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 48065..48612 Replicon plasmid unnamed2
Accession NZ_CP065969
Organism Escherichia coli strain FDAARGOS_1058

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag I6I15_RS00400 Protein ID WP_000969996.1
Coordinates 48065..48346 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2W8GN83
Locus tag I6I15_RS00405 Protein ID WP_000079940.1
Coordinates 48343..48612 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I15_RS00355 43481..43894 - 414 WP_000465034.1 hypothetical protein -
I6I15_RS00360 44464..44721 + 258 WP_000343101.1 hypothetical protein -
I6I15_RS00365 44721..45311 + 591 WP_000198612.1 hypothetical protein -
I6I15_RS00370 45329..45676 - 348 WP_000142456.1 hypothetical protein -
I6I15_RS00375 45805..46140 + 336 WP_001080730.1 colicin 1A immunity protein -
I6I15_RS00380 46171..46338 - 168 Protein_58 hypothetical protein -
I6I15_RS00385 46447..47049 + 603 WP_000517686.1 hypothetical protein -
I6I15_RS00390 47105..47599 + 495 WP_021561690.1 hypothetical protein -
I6I15_RS00395 47599..47865 + 267 WP_000627828.1 hypothetical protein -
I6I15_RS00400 48065..48346 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I15_RS00405 48343..48612 - 270 WP_000079940.1 hypothetical protein Antitoxin
I6I15_RS00410 48667..48825 - 159 WP_000841008.1 hypothetical protein -
I6I15_RS00415 49521..50552 - 1032 WP_000907875.1 replication initiation protein -
I6I15_RS00420 51525..51788 + 264 WP_001324596.1 ash family protein -
I6I15_RS00425 51706..51993 + 288 WP_000074849.1 conjugal transfer protein TraA -
I6I15_RS00430 52435..52968 + 534 WP_001303319.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..83533 83533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T183703 WP_000969996.1 NZ_CP065969:c48346-48065 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T183703 NZ_CP087165:3995520-3996095 [Pseudomonas sichuanensis]
ATGAAGCATTCCTCCTTCACAGCCCTTTACGACGCCAACGTTCTTTATCCCGCCCCACTGCGTGACTTGCTGATGAACCT
TGCACTGACGGGCGTGTACCGCGCCCGCTGGTTAGCCAGGATTCATGACGAGTGGAAGCGCAATCTACTGATCAATCGCC
CGGACCTTGACCGAACGCAGCTAGATCGCACGTCGGGCCTTATGGATGAGGCAGTGCCCGACGCACTGGTCAGCGATTAC
GAGCCACTGATGGGCGGGCTGGATCTGCCGGATGAGGATGATCGCCATGTCCTCGCCGCCGCCATCAAGTGCAACGCCTC
GGTGATCGTGACCTTCAATCTCAAGGACTTTCCCGACACCGCGCTTGGTAGCTTCGATATCGAAGCACTGCATCCCGATG
ATTTCATCGCCGACCTCCGGGACTTGGACAAGGCCGCGGTGCTTGAAGCGGCCCAGCGGCAGCGCCAGTCATTGAAGAAC
CCTGCCCTGAGCGTGCAGGCTTATCTGGACAAGCTGCTCCAGCAAAAGCTGCCTGAGTCGGTAAAACTGCTTTCCGAGTT
CAGGTTCTTGCTCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10274.60 Da        Isoelectric Point: 7.2057

>AT183703 WP_000079940.1 NZ_CP065969:c48612-48343 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDMLSHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT183703 NZ_CP087165:3995056-3995523 [Pseudomonas sichuanensis]
ATGACCACCACCGACCTTTCGCGCAACATGCTTCCCGATGACAACGAGATTGCCGTGGCCGTCGAATCAAGCCGCACGCT
CGCCGCCTTTCTCTCGACCGCAGCGCACACCCAACGGATCGAGCTGCTCAATGACGCGAATCAGCGCCAGGTCGTGGAGG
TTCCCACCTTTGCCCTGCGCCTGTTTGGCGAAATCCTCAGCGAACTGGCACTGGGCAACGCCGTCAAGGTCGTGCCGATC
CACGCCGAGCTGACCACTCAGGAAGCAGCCGACCTGCTCAATGTTTCCCGCCCGCATCTGGTAAAGCTGCTGGACGAGGG
GTTGATGCCCCACACCAAGACGGGCCGTCACCGCCGGGTCAAATTCGCGGATTTGGTGGCCTACAAGAACAAACGTGATG
CCATCAGCCGTACCGCGATGGACGAACTGGCGGCCCAGGCACAGGACTTAAGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W8GN83

References