Detailed information of TA system TA183593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2390725..2391691
• Replicon: chromosome
• Accession: NZ_CP065918
• Organism: Yersinia pestis EV NIIEG

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: AH66_RS10780
• Protein ID: WP_002210981.1
• Coordinates: 2391233..2391691 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: AH66_RS10775
• Protein ID: WP_002210982.1
• Coordinates: 2390725..2391171 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH66_RS10755	2386315..2387289	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
AH66_RS10760	2387452..2387955	+	504	WP_002210984.1	thiol peroxidase	-
AH66_RS10765	2388208..2388666	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
AH66_RS10770	2388813..2390390	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
AH66_RS10775	2390725..2391171	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
AH66_RS10780	2391233..2391691	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
AH66_RS10785	2391701..2392762	-	1062	WP_002210980.1	YcjF family protein	-
AH66_RS10790	2392759..2394156	-	1398	WP_002210979.1	YcjX family protein	-
AH66_RS10795	2394137..2394379	-	243	WP_002216375.1	phage shock protein PspD	-
AH66_RS10800	2394464..2394823	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
AH66_RS10805	2394823..2395050	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
AH66_RS10810	2395212..2395877	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2388208..2388666	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T183593 WP_002210981.1 NZ_CP065918:2391233-2391691 [Yersinia pestis EV NIIEG]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T183593 NZ_CP087123:732159-732644 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT183593 WP_002210982.1 NZ_CP065918:2390725-2391171 [Yersinia pestis EV NIIEG]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT183593 NZ_CP087123:731869-732162 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1