Detailed information of TA system TA183576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4564670..4565928
• Replicon: chromosome
• Accession: NZ_CP065867
• Organism: Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I9X29_RS21155
• Protein ID: WP_023099862.1
• Coordinates: 4564670..4565425 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: I9X29_RS21160
• Protein ID: WP_003086329.1
• Coordinates: 4565560..4565928 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9X29_RS21145	4559841..4562384	+	2544	WP_126587538.1	acyl-homoserine-lactone acylase QuiP	-
I9X29_RS21150	4562539..4563900	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
I9X29_RS21155	4564670..4565425	-	756	WP_023099862.1	RES family NAD+ phosphorylase	Toxin
I9X29_RS21160	4565560..4565928	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
I9X29_RS21165	4566001..4567287	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
I9X29_RS21170	4567343..4568932	-	1590	WP_003140637.1	aldehyde dehydrogenase family protein	-
I9X29_RS21175	4569010..4569486	+	477	WP_009877993.1	elongation factor GreAB	-
I9X29_RS21180	4569489..4569764	-	276	WP_185830314.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28264.40 Da
• Isoelectric Point: 7.7294

>T183576 WP_023099862.1 NZ_CP065867:c4565425-4564670 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVETLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T183576 NZ_CP087122:323302-323670 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT183576 WP_003086329.1 NZ_CP065867:c4565928-4565560 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT183576 NZ_CP087122:323084-323305 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7