Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1849236..1850744 Replicon chromosome
Accession NZ_CP065866
Organism Pseudomonas aeruginosa strain TJ2019-017

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag I9X27_RS08625 Protein ID WP_003119682.1
Coordinates 1849236..1849823 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag I9X27_RS08630 Protein ID WP_003091607.1
Coordinates 1849890..1850744 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X27_RS08620 1845491..1848970 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
I9X27_RS08625 1849236..1849823 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
I9X27_RS08630 1849890..1850744 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
I9X27_RS08635 1850841..1853006 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
I9X27_RS08640 1853181..1855055 + 1875 WP_003117607.1 MFS transporter -
I9X27_RS08645 1855116..1855325 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T183567 WP_003119682.1 NZ_CP065866:1849236-1849823 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T183567 NZ_CP087114:c798830-798519 [Bartonella machadoae]
ATGGTAGCGATAATAAAAACAACAGATGAATTTGATGAATGGTTAGAAAAGCTTAAAGACAGAAAAGCTGCCGATATAAT
TCTTGCAAGACTTCATAAAATTCGTTCAGGGCTTTTAGGTGATGTTAAATTTTTTCATGGTATAGGTGAATTACGTATCC
ACTATGGCGCGGGTTACAGGATTTATTTCACTCAAAAAGGTAATAAAATCATTATATTGCTTTGTGGTGGTGACAAATCC
ACACAATCCAAAGATATTCAAAAAGCCTTATCTCTCTTGGAGGACCTTAAAAATGAAATTGAAAACCTTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT183567 WP_003091607.1 NZ_CP065866:1849890-1850744 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT183567 NZ_CP087114:c798538-798257 [Bartonella machadoae]
ATGAAATTGAAAACCTTTAACTTTGAAAAACACCTCACAACACCAGAATCTCAAGAAGTCTTTTTAAACGAAGCCTTCAA
AACTGGTGATGCTGCGCATATCGCAGATGCTCTTGGTATCGTTGCCCGCGCTCAAAATATGAGTGCATTAGCAAAGGAAA
CAAACCGTGAACGCAGTGGTTTATATCGCTCCCTTAGCAAAACGGGTGACCCTAGACTTTCTACTTTAGTTGCTGTGCTC
TCTGCCCTTAATTTGCAATTAAGCGTACAATCTACTCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References