Detailed information of TA system TA183544

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2095456..2095755
• Replicon: chromosome
• Accession: NZ_CP065857
• Organism: Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: I1A60_RS10305
• Protein ID: WP_072353918.1
• Coordinates: 2095579..2095755 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2095456..2095511 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1A60_RS10265	2091014..2091193	+	180	WP_000669791.1	hypothetical protein	-
I1A60_RS10270	2091504..2091764	+	261	WP_001791826.1	hypothetical protein	-
I1A60_RS10275	2091817..2092167	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
I1A60_RS10280	2092678..2093013	-	336	Protein_1986	SH3 domain-containing protein	-
I1A60_RS10285	2093664..2094155	-	492	WP_000920038.1	staphylokinase	-
I1A60_RS10290	2094346..2095101	-	756	WP_000861038.1	CHAP domain-containing protein	-
I1A60_RS10295	2095113..2095367	-	255	WP_000611512.1	phage holin	-
I1A60_RS10300	2095419..2095526	+	108	WP_001791821.1	hypothetical protein	-
-	2095448..2095587	+	140	NuclAT_0	-	-
-	2095448..2095587	+	140	NuclAT_0	-	-
-	2095448..2095587	+	140	NuclAT_0	-	-
-	2095448..2095587	+	140	NuclAT_0	-	-
-	2095456..2095511	+	56	-	-	Antitoxin
I1A60_RS10305	2095579..2095755	-	177	WP_072353918.1	putative holin-like toxin	Toxin
I1A60_RS10310	2095898..2096272	-	375	WP_000340977.1	hypothetical protein	-
I1A60_RS10315	2096328..2096615	-	288	WP_001262620.1	hypothetical protein	-
I1A60_RS10320	2096661..2096813	-	153	WP_001000058.1	hypothetical protein	-
I1A60_RS10325	2096806..2097384	-	579	Protein_1995	structural protein	-
I1A60_RS10330	2097385..2098197	+	813	Protein_1996	sphingomyelin phosphodiesterase	-
I1A60_RS10335	2098435..2099451	-	1017	WP_000595326.1	bi-component leukocidin LukGH subunit G	-
I1A60_RS10340	2099473..2100525	-	1053	WP_000791419.1	bi-component leukocidin LukGH subunit H	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2091817..2109732	17915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T183544 WP_072353918.1 NZ_CP065857:c2095755-2095579 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T183544 NZ_CP087110:1820640-1820743 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 56 bp

>AT183544 NZ_CP065857:2095456-2095511 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin