Detailed information of TA system TA183291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 960081..961056
• Replicon: chromosome
• Accession: NZ_CP065739
• Organism: Bacillus tropicus strain FDAARGOS_920

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: I6G77_RS04960
• Protein ID: WP_033691453.1
• Coordinates: 960081..960818 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D8GY54
• Locus tag: I6G77_RS04965
• Protein ID: WP_000594608.1
• Coordinates: 960931..961056 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G77_RS04940	955755..956537	+	783	WP_042515126.1	class I SAM-dependent methyltransferase	-
I6G77_RS04945	956714..958399	-	1686	WP_052495880.1	alpha-keto acid decarboxylase family protein	-
I6G77_RS04950	958506..958988	+	483	WP_000191902.1	MarR family winged helix-turn-helix transcriptional regulator	-
I6G77_RS04955	959155..959892	+	738	WP_001980023.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
I6G77_RS04960	960081..960818	+	738	WP_033691453.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
I6G77_RS04965	960931..961056	+	126	WP_000594608.1	hypothetical protein	Antitoxin
I6G77_RS04970	961132..961308	+	177	WP_000852618.1	hypothetical protein	-
I6G77_RS04975	961452..962921	+	1470	WP_001979053.1	beta-Ala-His dipeptidase	-
I6G77_RS04980	963502..963972	-	471	WP_042515124.1	DUF5065 family protein	-
I6G77_RS04985	964427..965086	+	660	WP_042515123.1	CatB-related O-acetyltransferase	-
I6G77_RS04990	965419..966036	+	618	WP_142309569.1	SGNH/GDSL hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28433.19 Da
• Isoelectric Point: 8.2672

>T183291 WP_033691453.1 NZ_CP065739:960081-960818 [Bacillus tropicus]
VISNIRIGLFILVIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEVAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T183291 NZ_CP086862:1561538-1561801 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4878.27 Da
• Isoelectric Point: 3.9507

>AT183291 WP_000594608.1 NZ_CP065739:960931-961056 [Bacillus tropicus]
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEDLEDELKRK

Nucleotide

• Length: 126 bp

>AT183291 NZ_CP086862:1561788-1562003 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U6H9M7