Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-Xre
Location 194977..195956 Replicon plasmid unnamed
Accession NZ_CP065685
Organism Burkholderia humptydooensis strain FDAARGOS_899

Toxin (Protein)


Gene name ParT Uniprot ID A0A7U4P7N2
Locus tag I6G56_RS00960 Protein ID WP_009917390.1
Coordinates 194977..195456 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID A0A7U4P7N6
Locus tag I6G56_RS00965 Protein ID WP_006029252.1
Coordinates 195453..195956 (-) Length 168 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G56_RS00940 191004..191963 + 960 WP_141668135.1 hypothetical protein -
I6G56_RS00945 191975..192262 + 288 WP_006029250.1 PAAR domain-containing protein -
I6G56_RS00950 192418..192822 - 405 WP_144411843.1 hypothetical protein -
I6G56_RS00955 192949..194574 + 1626 WP_043283261.1 hypothetical protein -
I6G56_RS00960 194977..195456 - 480 WP_009917390.1 RES family NAD+ phosphorylase Toxin
I6G56_RS00965 195453..195956 - 504 WP_006029252.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
I6G56_RS00970 196023..197506 - 1484 Protein_193 site-specific integrase -
I6G56_RS00975 197512..198336 - 825 WP_006029254.1 hypothetical protein -
I6G56_RS00980 198520..199398 - 879 WP_006029255.1 3'-5' exonuclease -
I6G56_RS00985 199444..199701 - 258 WP_080595248.1 hypothetical protein -
I6G56_RS00990 199767..200108 - 342 WP_009917391.1 hypothetical protein -
I6G56_RS00995 200089..200400 - 312 WP_009917392.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bspR2 / bspI2 1..305114 305114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-142)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(119-164)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17326.66 Da        Isoelectric Point: 5.6628

>T183176 WP_009917390.1 NZ_CP065685:c195456-194977 [Burkholderia humptydooensis]
MTVALWRIATDTPDYTADDLSGEGAKRTGGRWNRSGRAVLYTASNIALACLETVVHLSGGDLPLNRYLVRLEVPDEVWAK
ARTLDATSAPVGWDALPAGKVSLDLGDAWLSEGATALYCVPSVVVPEEVNVLINPAHLDTRHITATKLRRWTYDARVWA

Download         Length: 480 bp

>T183176 NZ_CP086759:c820975-820586 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 168 a.a.        Molecular weight: 18484.30 Da        Isoelectric Point: 9.6518

>AT183176 WP_006029252.1 NZ_CP065685:c195956-195453 [Burkholderia humptydooensis]
MSAIEKRHALPARARPRAVEPHELELLDFQRIYRASPMERIDWIKHGVDAHTVILLADRMATTQDRLMGVLGFPRTTVVR
KSKAKQPLSTEHTERVVGLSKLIGQVQSMVEESGEPAGFDAAHWVAQWIERTNPALGGRKPAELMDTVAGQELVGAVLAR
MQSGAYA

Download         Length: 504 bp

>AT183176 NZ_CP086759:c821239-820982 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4P7N2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4P7N6

References