Detailed information of TA system TA183146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 5188412..5188992
• Replicon: chromosome
• Accession: NZ_CP065668
• Organism: Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6G66_RS24370
• Protein ID: WP_197954921.1
• Coordinates: 5188412..5188792 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A072THC0
• Locus tag: I6G66_RS24375
• Protein ID: WP_016448366.1
• Coordinates: 5188789..5188992 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G66_RS24350	5183741..5184982	+	1242	WP_016448371.1	ABC transporter substrate-binding protein	-
I6G66_RS24355	5184979..5185737	+	759	WP_016452684.1	ABC transporter permease	-
I6G66_RS24360	5185772..5187352	-	1581	WP_197954918.1	Ig-like domain repeat protein	-
I6G66_RS24365	5187582..5188334	+	753	WP_197954919.1	helix-turn-helix transcriptional regulator	-
I6G66_RS24370	5188412..5188792	-	381	WP_197954921.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G66_RS24375	5188789..5188992	-	204	WP_016448366.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I6G66_RS24380	5189143..5189955	+	813	WP_183019685.1	glucose 1-dehydrogenase	-
I6G66_RS24385	5190065..5191741	+	1677	WP_197954925.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-114)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13893.30 Da
• Isoelectric Point: 9.3895

>T183146 WP_197954921.1 NZ_CP065668:c5188792-5188412 [Delftia acidovorans]
MNPVLVDTSVWIDHFRQGNPHLAQLLQQDMALMHPLVLGELACGTPPARARTLADLQRLKPARQASMREVLALIEREQLF
GLGCGLVDITLLASALMSSGASLWSRDKRLHALAQRFGIAYRSVLP

Nucleotide

• Length: 381 bp

>T183146 NZ_CP086724:371180-371527 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7499.60 Da
• Isoelectric Point: 4.5702

>AT183146 WP_016448366.1 NZ_CP065668:c5188992-5188789 [Delftia acidovorans]
MRTTVTIDDALYEEALELAEPEMDKADLFREAIKTFVRVQAAKRLAALGGSAPDMREIPRRPQGIEP

Nucleotide

• Length: 204 bp

>AT183146 NZ_CP086724:371527-371826 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A072THC0