Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2639534..2640165 Replicon chromosome
Accession NZ_CP065640
Organism Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)


Gene name Hha Uniprot ID L0MF14
Locus tag I6G83_RS12260 Protein ID WP_015671220.1
Coordinates 2639534..2639737 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A140F0B9
Locus tag I6G83_RS12265 Protein ID WP_061324804.1
Coordinates 2639797..2640165 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G83_RS12240 2634726..2635148 + 423 WP_015671216.1 hypothetical protein -
I6G83_RS12245 2635183..2636526 - 1344 WP_054305427.1 NCS2 family permease -
I6G83_RS12250 2636596..2638383 - 1788 WP_054305426.1 adenine deaminase -
I6G83_RS12255 2638521..2639453 + 933 WP_054305425.1 LysR family transcriptional regulator -
I6G83_RS12260 2639534..2639737 - 204 WP_015671220.1 hemolysin expression modulator Hha Toxin
I6G83_RS12265 2639797..2640165 - 369 WP_061324804.1 Hha toxicity modulator TomB Antitoxin
I6G83_RS12270 2640522..2640875 - 354 WP_054305423.1 hypothetical protein -
I6G83_RS12275 2641040..2641189 + 150 WP_156484024.1 hypothetical protein -
I6G83_RS12280 2641186..2641890 + 705 WP_054305422.1 ABC transporter ATP-binding protein -
I6G83_RS12285 2641887..2642753 + 867 WP_054305421.1 metal ABC transporter permease -
I6G83_RS12290 2642769..2643644 + 876 WP_054305420.1 metal ABC transporter substrate-binding protein -
I6G83_RS12295 2643742..2643882 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
I6G83_RS12300 2643892..2644146 - 255 WP_015671227.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8049.33 Da        Isoelectric Point: 7.9816

>T183107 WP_015671220.1 NZ_CP065640:c2639737-2639534 [Serratia rubidaea]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T183107 NZ_CP086664:4053039-4053257 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14393.20 Da        Isoelectric Point: 4.7790

>AT183107 WP_061324804.1 NZ_CP065640:c2640165-2639797 [Serratia rubidaea]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKRRLFRMFSGEVCCTKMKT

Download         Length: 369 bp

>AT183107 NZ_CP086664:4052638-4053012 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857EAE6

Antitoxin

Source ID Structure
AlphaFold DB A0A140F0B9

References