Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2941..3166 Replicon chromosome
Accession NZ_CP065624
Organism Escherichia coli strain FDAARGOS_941

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag I6G98_RS00785 Protein ID WP_000813254.1
Coordinates 2941..3096 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 3108..3166 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G98_RS00765 389..1072 - 684 WP_032359563.1 antiterminator -
I6G98_RS00770 1069..1434 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
I6G98_RS00775 1435..2493 - 1059 WP_197932854.1 DUF968 domain-containing protein -
I6G98_RS00780 2495..2773 - 279 WP_197932975.1 hypothetical protein -
I6G98_RS00785 2941..3096 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 3108..3166 + 59 - - Antitoxin
I6G98_RS00790 3748..4164 - 417 WP_005069274.1 hypothetical protein -
I6G98_RS00795 4261..4416 - 156 Protein_6 ead/Ea22-like family protein -
I6G98_RS00805 5678..5983 - 306 Protein_8 ead/Ea22-like family protein -
I6G98_RS00810 5970..6275 - 306 WP_001266147.1 DUF4406 domain-containing protein -
I6G98_RS00815 6272..6694 - 423 WP_032359565.1 DUF977 family protein -
I6G98_RS00820 6735..7805 - 1071 WP_073840766.1 phage replisome organizer -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T183053 WP_000813254.1 NZ_CP065624:c3096-2941 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T183053 NZ_CP086627:1115325-1115732 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 59 bp

>AT183053 NZ_CP065624:3108-3166 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0


Antitoxin

Download structure file

References