Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4046453..4047084 Replicon chromosome
Accession NZ_CP065615
Organism Escherichia coli strain FDAARGOS_943

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LJQ2
Locus tag I6H00_RS20335 Protein ID WP_001259387.1
Coordinates 4046809..4047084 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag I6H00_RS20330 Protein ID WP_000593554.1
Coordinates 4046453..4046812 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H00_RS20300 4041564..4042037 + 474 WP_038339111.1 PTS sugar transporter subunit IIA -
I6H00_RS20305 4042034..4042315 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
I6H00_RS20310 4042392..4043751 + 1360 Protein_3962 PTS galactitol transporter subunit IIC -
I6H00_RS20315 4043744..4045252 + 1509 WP_001298718.1 carbohydrate kinase -
I6H00_RS20320 4045242..4045511 + 270 WP_000933060.1 HPr family phosphocarrier protein -
I6H00_RS20325 4045543..4046403 + 861 WP_001131788.1 class II aldolase -
I6H00_RS20330 4046453..4046812 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6H00_RS20335 4046809..4047084 - 276 WP_001259387.1 type II toxin-antitoxin system HicA family toxin Toxin
I6H00_RS20340 4047157..4048281 - 1125 WP_001314210.1 ABC transporter permease -
I6H00_RS20345 4048281..4051016 - 2736 WP_096854231.1 ribosome-associated ATPase/putative transporter RbbA -
I6H00_RS20350 4051013..4052080 - 1068 WP_038339113.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4041030..4055940 14910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10214.91 Da        Isoelectric Point: 10.7076

>T183043 WP_001259387.1 NZ_CP065615:c4047084-4046809 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESQVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T183043 NZ_CP086626:c4731839-4731666 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT183043 WP_000593554.1 NZ_CP065615:c4046812-4046453 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT183043 NZ_CP086626:c4732163-4731867 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LJQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References