Detailed information of TA system TA182852

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 399733..400312
• Replicon: chromosome
• Accession: NZ_CP065515
• Organism: Staphylococcus aureus strain GDY8P96A

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IQE12_RS01850
• Protein ID: WP_001025401.1
• Coordinates: 399733..399978 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	399947..400312 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQE12_RS01805	395724..396338	+	615	WP_000191459.1	hypothetical protein	-
IQE12_RS01810	396335..396481	-	147	WP_001013104.1	hypothetical protein	-
IQE12_RS01815	396711..397295	-	585	WP_181187920.1	hypothetical protein	-
IQE12_RS01820	397313..397771	-	459	WP_181187921.1	toxin	-
IQE12_RS01825	397793..398119	-	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
IQE12_RS01830	398282..398491	+	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
IQE12_RS01835	398530..399306	+	777	WP_031886646.1	Rha family transcriptional regulator	-
IQE12_RS01840	399335..399478	+	144	WP_000939498.1	hypothetical protein	-
IQE12_RS01845	399468..399677	-	210	WP_181187922.1	hypothetical protein	-
IQE12_RS01850	399733..399978	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IQE12_RS01855	399947..400312	-	366	WP_016170627.1	hypothetical protein	Antitoxin
IQE12_RS01860	400367..400582	+	216	WP_001097552.1	hypothetical protein	-
IQE12_RS01865	400607..400870	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IQE12_RS01870	400883..401044	+	162	WP_084570111.1	DUF1270 family protein	-
IQE12_RS01875	401123..401446	+	324	WP_000174996.1	hypothetical protein	-
IQE12_RS01880	401461..401823	+	363	WP_084570110.1	hypothetical protein	-
IQE12_RS01885	401820..402986	+	1167	WP_084570109.1	DUF2800 domain-containing protein	-
IQE12_RS01890	403012..403569	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	394393..439795	45402

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T182852 WP_001025401.1 NZ_CP065515:399733-399978 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T182852 NZ_CP086616:2669376-2670698 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT182852 NZ_CP065515:c400312-399947 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin