Detailed information of TA system TA182847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4684581..4685400
• Replicon: chromosome
• Accession: NZ_CP065474
• Organism: Klebsiella michiganensis strain 7525

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: I6F39_RS22420
• Protein ID: WP_004110819.1
• Coordinates: 4685143..4685400 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6F39_RS22415
• Protein ID: WP_197663569.1
• Coordinates: 4684581..4685132 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6F39_RS22400	4679972..4681369	+	1398	WP_009654185.1	MFS transporter	-
I6F39_RS22405	4681492..4682832	+	1341	WP_139530877.1	carbohydrate porin	-
I6F39_RS22410	4682935..4684563	-	1629	WP_049077420.1	SAM-dependent methyltransferase	-
I6F39_RS22415	4684581..4685132	-	552	WP_197663569.1	N-acetyltransferase	Antitoxin
I6F39_RS22420	4685143..4685400	-	258	WP_004110819.1	YjhX family toxin	Toxin
I6F39_RS22425	4686076..4687260	+	1185	WP_049105906.1	mannonate dehydratase	-
I6F39_RS22430	4687334..4688809	+	1476	WP_004847988.1	fructuronate reductase	-
I6F39_RS22435	4688948..4689724	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T182847 WP_004110819.1 NZ_CP065474:c4685400-4685143 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T182847 NZ_CP086616:c971870-971496 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19996.78 Da
• Isoelectric Point: 6.4897

>AT182847 WP_197663569.1 NZ_CP065474:c4685132-4684581 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHSLFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT182847 NZ_CP086616:c972291-971917 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2