Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1122485..1123139 Replicon chromosome
Accession NZ_CP065460
Organism Klebsiella pneumoniae strain Gordon

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag I5M58_RS05590 Protein ID WP_004144731.1
Coordinates 1122732..1123139 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I5M58_RS05585 Protein ID WP_002916312.1
Coordinates 1122485..1122751 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M58_RS05560 1117641..1119074 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I5M58_RS05565 1119193..1119921 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I5M58_RS05570 1119971..1120282 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I5M58_RS05575 1120446..1121105 + 660 WP_002916317.1 hemolysin III family protein -
I5M58_RS05580 1121256..1122239 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I5M58_RS05585 1122485..1122751 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I5M58_RS05590 1122732..1123139 + 408 WP_004144731.1 protein YgfX Toxin
I5M58_RS05595 1123146..1123667 - 522 WP_002916308.1 flavodoxin FldB -
I5M58_RS05600 1123768..1124664 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I5M58_RS05605 1124687..1125400 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I5M58_RS05610 1125406..1127139 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T182768 WP_004144731.1 NZ_CP065460:1122732-1123139 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T182768 NZ_CP086566:c2520364-2520263 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182768 WP_002916312.1 NZ_CP065460:1122485-1122751 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182768 NZ_CP086566:2520139-2520318 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References